Activin A Receptor Type II A (ACVR2A) Recombinant Protein | ACVR2A recombinant protein
Recombinant Activin A Receptor Type II A (ACVR2A)
MGHHHHHHSGSEF-KNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRL
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
Uniprot Description
ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.
Protein type: Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Protein kinase, TKL; EC 2.7.11.30; Kinase, protein; Motility/polarity/chemotaxis; TKL group; STKR family; Type2 subfamily
Cellular Component: cell surface; membrane; cytoplasm; integral to membrane; receptor complex
Molecular Function: activin receptor activity; protein self-association; metal ion binding; nucleotide binding; activin receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; PDZ domain binding; transferase activity; protein serine/threonine kinase activity; protein binding; growth factor binding; transferase activity, transferring phosphorus-containing groups; activin binding; coreceptor activity; kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: embryonic skeletal development; positive regulation of erythrocyte differentiation; male gonad development; regulation of BMP signaling pathway; activin receptor signaling pathway; regulation of signal transduction; Sertoli cell proliferation; gastrulation with mouth forming second; positive regulation of bone mineralization; protein amino acid phosphorylation; anterior/posterior pattern formation; BMP signaling pathway; positive regulation of osteoblast differentiation; positive regulation of activin receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; spermatogenesis; mesoderm development; sperm ejaculation; regulation of nitric-oxide synthase activity; positive regulation of follicle-stimulating hormone secretion; positive regulation of protein amino acid phosphorylation; determination of left/right symmetry; phosphorylation; penile erection
Research Articles on ACVR2A
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Product Notes
The ACVR2A acvr2a (Catalog #AAA2011260) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Activin A Receptor Type II A (ACVR2A) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the ACVR2A acvr2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-KNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRL. It is sometimes possible for the material contained within the vial of "Activin A Receptor Type II A (ACVR2A), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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