Rabbit anti-Mouse Acvr2a Polyclonal Antibody | anti-Acvr2a antibody

Acvr2a, NT (Acvr2a, Acvr2, Activin receptor type-2A, Activin receptor type IIA) (Biotin)

Cat. Num. AAA6271422

• Gene Names: Acvr2a; Acvr2; ActrIIa; TactrII
• Reactivity: Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Acvr2a; Polyclonal Antibody; NT (Acvr2a; Acvr2; Activin receptor type-2A; Activin receptor type IIA) (Biotin); Activin receptor type IIA; anti-Acvr2a antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-Acvr2a antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Mouse Acvr2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human Mouse Acvr2a.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Mouse Acvr2a Antibody (N-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Acvr2a antibody detected the Acvr2a protein (arrow).)

Related Product Information for anti-Acvr2a antibody

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Product Categories/Family for anti-Acvr2a antibody

Antibodies; Activin

References

Perron, J.C., et al. PLoS ONE 4 (12), E8198 (2009): Morita, S., et al. PLoS ONE 4 (1), E4212 (2009): Kamiya, N., et al. Development 135(22):3801-3811(2008). Xia, Y., et al. J. Biol. Chem. 282(25):18129-18140(2007). Lee, Y.J., et al. Genesis 44(10):487-494(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 160358785
• NCBI GeneID: 11480
• NCBI Accession #: NP_031422.3
• NCBI GenBank Nucleotide #: NM_007396.4
• UniProt Accession #: P27038
• Molecular Weight: 57,890 Da
• NCBI Official Full Name: activin receptor type-2A
• NCBI Official Synonym Full Names: activin receptor IIA
• NCBI Official Symbol: Acvr2a
• NCBI Official Synonym Symbols: Acvr2; ActrIIa; TactrII
• NCBI Protein Information: activin receptor type-2A
• UniProt Protein Name: Activin receptor type-2A
• Protein Family: Activin receptor
• UniProt Gene Name: Acvr2a
• UniProt Synonym Gene Names: Acvr2; ACTR-IIA
• UniProt Entry Name: AVR2A_MOUSE

Uniprot Description

ACVR2A: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Kinase, protein; TKL group; STKR family; Type2 subfamily

Cellular Component: cell surface; cytoplasm; integral to membrane; membrane; receptor complex

Molecular Function: activin binding; activin receptor activity; activin receptor activity, type II; ATP binding; coreceptor activity; growth factor binding; kinase activity; metal ion binding; nucleotide binding; PDZ domain binding; protein binding; protein kinase activity; protein self-association; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; transferase activity; transmembrane receptor protein serine/threonine kinase activity

Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; BMP signaling pathway; determination of left/right symmetry; embryonic skeletal development; gastrulation with mouth forming second; male gonad development; mesoderm development; penile erection; phosphorylation; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; positive regulation of osteoblast differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of BMP signaling pathway; regulation of nitric-oxide synthase activity; regulation of signal transduction; Sertoli cell proliferation; sperm ejaculation; spermatogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway