Activin receptor type-1 (Acvr1) Recombinant Protein | Acvr1 recombinant protein
Recombinant Mouse Activin receptor type-1 (Acvr1)
NCBI and Uniprot Product Information
Uniprot Description
ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.11.30; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily
Cellular Component: membrane; apical part of cell; integral to plasma membrane; integral to membrane; activin receptor complex
Molecular Function: protein homodimerization activity; metal ion binding; nucleotide binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; activin receptor activity, type I; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; growth factor binding; transferase activity, transferring phosphorus-containing groups; activin binding; kinase activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: heart development; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; gastrulation; protein amino acid phosphorylation; germ cell development; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; mesoderm development; neural crest cell migration; pharyngeal system development; in utero embryonic development; peptidyl-threonine phosphorylation; gastrulation with mouth forming second; positive regulation of bone mineralization; negative regulation of signal transduction; patterning of blood vessels; negative regulation of activin receptor signaling pathway; positive regulation of osteoblast differentiation; embryonic development; mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; regulation of ossification; determination of left/right symmetry; phosphorylation; urogenital system development; G1/S transition of mitotic cell cycle
Research Articles on Acvr1
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Product Notes
The Acvr1 acvr1 (Catalog #AAA954721) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 21-123. The amino acid sequence is listed below: VEDEKPKVNQ KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF HLE. It is sometimes possible for the material contained within the vial of "Activin receptor type-1 (Acvr1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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