TLR1 Fc Chimera Active Protein
TLR1 Fc Chimera, Recombinant, Human (Toll-like receptor 1, CD281, DKFZp547I0610, DKFZp564I0682, KIAA0012, MGC104956, MGC126311, MGC126312, rsc786, TIL, Toll/interleukin-1 receptor-like protein)
Purity
Highly Purified90% by SDSPAGE under reducing conditions and visualized by silver stain.
Synonyms
TLR1 Fc Chimera; Recombinant; Human (Toll-like receptor 1; CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; rsc786; TIL; Toll/interleukin-1 receptor-like protein); TLR1 Fc Chimera active protein
Specificity
Recognizes human TRL1.
Purity/Purification
Highly Purified
90% by SDSPAGE under reducing conditions and visualized by silver stain.
90% by SDSPAGE under reducing conditions and visualized by silver stain.
Form/Format
Lyophilized from a 0.2um filtered solution in PBS. Reconstitute at 100ug/ml in PBS.
Application Notes
Suitable for use in ELISA.
Immunogen
NS0-derived recombinant human TLR1, AAC34137.
Activity
Measured by its ability to bind biotinylated Pam3CysSerLys4 (PAM3CSK4).
Endotoxin Level
1.0 EU per 1ug of the protein by the LAL method.
Preparation and Storage
12 months from date of receipt, 20 to 70 degree C as supplied.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, 20 to 70 degree C under sterile conditions after reconstitution.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, 20 to 70 degree C under sterile conditions after reconstitution.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Related Product Information for TLR1 Fc Chimera active protein
The Tolllike family of molecules are type I transmembrane proteins that serve as pattern recognition receptors for microbial pathogens. There are at least eleven mouse and ten human TLRs that activate the innate immune system following exposure to a variety of microbial species (1, 2). TLRs contain a large number of leucinerich repeats (LRRs) and a cytoplasmic tail with one Tol l /IL1 receptor (TIR) domain. Mature human TLR1 consists of a 556 amino acid (aa) extracellular domain (ECD) with 20 LRRs, a 21 aa transmembrane segment, and a 185 aa cytoplasmic domain (3, 4). Within the ECD, human TLR1 shares 63% aa sequence identity with human TLR6 and 20% 43% aa sequence identitity with human TLR2, 3, 4, 5, 7, 8, 9, and 10. It shares 73% and 71% aa sequence identity with mouse and rat TLR1, respectively. TLR1 is expressed on the surface of macrophages, dendritic cells, and tonsillar epithelial cells in ligandindependent association with TLR2 (5 8). TLR2 additionally associates with TLR6 to form a functional complex with specificity for distinct but related microbial ligands (911). TLR1 and TLR2 cooperate in the recognition of bacterial and protozoal triacylated lipopeptides and glycosyl phosphatidylinositols (6,1012). Ligand binding induces TLR1 localization to lipid rafts followed by receptor internalization and activation of N F B (7,11,13).
Product Categories/Family for TLR1 Fc Chimera active protein
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Product Notes
The TLR1 Fc Chimera (Catalog #AAA636627) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. Suitable for use in ELISA. Researchers should empirically determine the suitability of the TLR1 Fc Chimera for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLR1 Fc Chimera, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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