Semaphorin 3C, Fc Chimera Active Protein
Semaphorin 3C, Fc Chimera, Recombinant, Human
Purity
Highly Purified95% by SDSPAGE under reducing conditions and visualized by silver stain.
Synonyms
Semaphorin 3C; Fc Chimera; Recombinant; Human; Fc Chimera active protein
Purity/Purification
Highly Purified
95% by SDSPAGE under reducing conditions and visualized by silver stain.
95% by SDSPAGE under reducing conditions and visualized by silver stain.
Form/Format
Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS. Reconstitute with 40-50% glycerol, PBS.
Activity
Measured by its ability to enhance the adhesion of SVEC4-10 cells (mouse endothelial cells,
ATCC: CRL-2181) to Fibronectin (Banu N. et al., FASEB J. 2006, 20(12):2150-2).
ATCC: CRL-2181) to Fibronectin (Banu N. et al., FASEB J. 2006, 20(12):2150-2).
Endotoxin Level
1.0 EU/1ug (LAL)
Preparation and Storage
12 months from date of receipt, 20 to 70 degree C as supplied.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, 20 to 70 degree C under sterile conditions after reconstitution.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, 20 to 70 degree C under sterile conditions after reconstitution.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Related Product Information for Semaphorin 3C, Fc Chimera active protein
Human Semaphorin 3C/Fc Chimera Semaphorin 3C (Sema3C; previously SemaE) is one of six Class 3 secreted semaphorins which share 40-50% aa identity among themselves. Class 3 semaphorins are potent chemorepellents that function in axon and/or vascular guidance during development, and may be upregulated in tumor progression (1, 2). The 751aa human Sema3C is highly modular. It contains a 20aa signal sequence, an ~500aa N-terminal Sema domain that forms a beta-propeller structure similar to that found in integrin molecules, a cysteine knot, a furin-type cleavage site, an Ig-like domain, and a C-terminal basic domain (1-3). Covalent dimerization plus cleavage at the C-terminus are required for activity of class 3 semaphorins (4). Human Sema3C shares at least 95% aa identity with mouse, rat, cow and dog Sema3C, and 89% and 75% aa identity with chick and zebrafish Sema3C, respectively. Type 3 semaphorins transduce signals through transmembrane plexins, either directly, or by binding associated neuropilin receptors (1, 2). Sema3C signaling is transduced by Plexin-D1 indirectly via neuropilin-1 or neuropilin-2 (5). Sema3C is expressed in all somitic motor neurons, in lung buds, and in cardiac neural crest cells during development (1, 5-8). Sema3C activates integrins in certain cells, so in addition to its repulsive activities, it sometimes acts as a chemoattractant (6, 9). In the developing nervous system, this chemoattraction appears to complement Sema3A
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Product Notes
The Semaphorin 3C, Fc Chimera (Catalog #AAA636520) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Semaphorin 3C, Fc Chimera, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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