Keratinocyte Growth Factor Human Active Protein | FGF7 active protein

Keratinocyte Growth Factor, Recombinant Human (KGF, Fibroblast Growth Factor 7, FGF-7)

Cat. Num. AAA650133

• Gene Names: FGF7; KGF; HBGF-7
• Purity: Highly Purified; 98% by SDS-PAGE and HPLC Endotoxin: 0.1ng/ug
• Synonyms: Keratinocyte Growth Factor Human; Keratinocyte Growth Factor; Recombinant Human (KGF; Fibroblast Growth Factor 7; FGF-7); FGF7 active protein

• Purity/Purification: Highly Purified; 98% by SDS-PAGE and HPLC Endotoxin: 0.1ng/ug
• Form/Format: Supplied as a lyophilized powder from 15mM sodium phosphate, pH 7.0, 0.25M sodium chloride. 11mg BSA. Reconstituted in PBS to a concentration of 0.5-1mg/ml. This solution can then be diluted into other aqueous solutions.

• Biological Activity: ED50 determined by the dose-dependent stimulation of thymidine uptake by KGF-responsive BaF3 cells is 10 ng/ml, corresponding to a specific activity of 1x10e7 units/mg.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Reconstitute to nominal volume by adding sterile PBS. Aliquot and store at -20 degree C. Reconstituted product is stable for 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for FGF7 active protein

Keratinocyte Growth Factor (KGF) is a potent mitogen for keratinocytes and epithelial cells. Human KGF is a 18.9kD protein containing 163 amino acid residues.

Product Categories/Family for FGF7 active protein

Growth Factors; Cytokines; Growth Factors-KGF

NCBI and Uniprot Product Information

• NCBI GI #: 4503705
• NCBI GeneID: 2252
• NCBI Accession #: NP_002000.1
• NCBI GenBank Nucleotide #: NM_002009.3
• UniProt Accession #: P21781; Q6FGV5; Q6RK68; Q96FG5
• Molecular Weight: 18.9kD
• NCBI Official Full Name: keratinocyte growth factor
• NCBI Official Synonym Full Names: fibroblast growth factor 7
• NCBI Official Symbol: FGF7
• NCBI Official Synonym Symbols: KGF; HBGF-7
• NCBI Protein Information: keratinocyte growth factor; FGF-7; OTTHUMP00000162252; heparin-binding growth factor 7
• UniProt Protein Name: Keratinocyte growth factor
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF7
• UniProt Synonym Gene Names: KGF
• UniProt Entry Name: FGF7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq]

Uniprot Description

Function: Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Subunit structure: Interacts with FGFBP1. Ref.4

Subcellular location: Secreted.

Tissue specificity: Epithelial cell.

Sequence similarities: Belongs to the heparin-binding growth factors family.