Interleukin 3 Active Protein | IL3 active protein

Interleukin 3, Recombinant, Human (IL-3)

Cat. Num. AAA650838

• Gene Names: IL3; IL-3; MCGF; MGC79398; MGC79399; MULTI-CSF
• Purity: Highly Purified; ~98% (SDS-PAGE)
• Synonyms: Interleukin 3; Recombinant; Human (IL-3); IL3 active protein

• Purity/Purification: Highly Purified; ~98% (SDS-PAGE)
• Form/Format: Supplied as a lyophilized powder. BSA free. Reconstitute with sterile dH2O or PBS to 0.1-1mg/ml.

• Activity: ED50 =0.1-0.25 ng/ml determined by the dose dependent stimulation of the proliferation of human TF-1 cells.
• Endotoxin Level: 0.1ng/ug
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

(Data show performance of human IL-3 compared to a leading competitor's protein in TF1 Cell Proliferation Assay.)

Product Categories/Family for IL3 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 28416915
• NCBI GeneID: 3562
• NCBI Accession #: NP_000579.2
• NCBI GenBank Nucleotide #: NM_000588.3
• UniProt Accession #: P08700; Q6GS87; Q6NZ78; Q6NZ79
• Molecular Weight: 15kD, 133 amino acid residues
• NCBI Official Full Name: interleukin-3
• NCBI Official Synonym Full Names: interleukin 3 (colony-stimulating factor, multiple)
• NCBI Official Symbol: IL3
• NCBI Official Synonym Symbols: IL-3; MCGF; MGC79398; MGC79399; MULTI-CSF
• NCBI Protein Information: interleukin-3; OTTHUMP00000065963; mast cell growth factor; mast-cell growth factor; P-cell stimulating factor; P-cell-stimulating factor; hematopoietic growth factor; multilineage-colony-stimulating factor; multipotential colony-stimulating factor
• UniProt Protein Name: Interleukin-3
• Protein Family: Interleukin
• UniProt Gene Name: IL3
• UniProt Entry Name: IL3_HUMAN

NCBI Description

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq]

Uniprot Description

Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Subunit structure: Monomer.

Subcellular location: Secreted.

Tissue specificity: Activated T-cells, mast cells, natural killer cells.

Sequence similarities: Belongs to the IL-3 family.