Interleukin 16 Active Protein
Interleukin 16, Recombinant, Human (LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289)
Purity
Highly PurifiedHighly purified (98% by SDS-PAGE analysis).
Synonyms
Interleukin 16; Recombinant; Human (LCF; prIL-16; FLJ16806; FLJ42735; FLJ44234; HST19289); Interleukin 16 active protein
Purity/Purification
Highly Purified
Highly purified (98% by SDS-PAGE analysis).
Highly purified (98% by SDS-PAGE analysis).
Form/Format
Supplied as a lyophilized powder in PBS, pH7.6.
Sequence
MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS
Biological Activity
Biological activity is determined by IL-6 abiltiy fo chemoattract CD4+ T-lymphocytes using a concentration range of 1-100ng/ml. For most known in vitro applications, IL-16 exerts it biological activity in the concentration range of 0.1-20ng/ml.
Endotoxin Level
0.1ng/ug
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O, carrier protein. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for Interleukin 16 active protein
IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer. Some IL-16 may exist as a monomer. Only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant crossspecies reactivity. Recombinant human IL-16 is a 13.5kD protein consisting of 130 amino acid residues.
Product Categories/Family for Interleukin 16 active protein
NCBI and Uniprot Product Information
Uniprot Description
IL16: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: Motility/polarity/chemotaxis; DNA-binding; Cytokine
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: extracellular space; cytoplasm; plasma membrane; nucleus
Molecular Function: cytokine activity
Biological Process: viral reproduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; leukocyte chemotaxis; immune response; induction of positive chemotaxis
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Product Notes
The Interleukin 16 (Catalog #AAA650467) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS. It is sometimes possible for the material contained within the vial of "Interleukin 16, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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