Fc Receptor-like 5 Active Protein | FCRLA active protein

Fc Receptor-like 5, Recombinant, Human (FCRL5, FcRH5)

Cat. Num. AAA636147

• Gene Names: FCRLA; FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2; RP11-474I16.5
• Purity: Purified; 95% (SDS­PAGE)
• Synonyms: Fc Receptor-like 5; Recombinant; Human (FCRL5; FcRH5); FCRLA active protein

• Purity/Purification: Purified; 95% (SDS­PAGE)
• Form/Format: Supplied as a lyophilized powder from 0.2um filtered solution in PBS. Reconstitute with sterile 100ug/ml PBS.

• Application Notes: SDS-PAGE: 110-120kD, reducing conditions.
• Biological Activity: Measured by its ability to bind human IgG with an estimated KD<30nM.
• Endotoxin Level: 1EU/ug (LAL)
• Preparation and Storage: Lyophilized powder may be stored at -70 degree C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -70 degree C. Reconstituted product is stable for 6 months at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for FCRLA active protein

Fc Receptor-Like 5 (FCRL5), also known as FcRH5, IRTA2, and CD307, is a 120kD protein with sequence homology to classical Fc receptors. The type 1 transmembrane FCRL proteins contain from three to nine immunoglobulin-l i ke domains. They are differentially expressed within the B cell lineage and can either promote or inhibit B cell proliferation and activation. According to testing, FCRL5 binds to purified human IgG with high affinity. Mature human FCRL5 consists of a 836aa extracellular domain (ECD) with nine Ig-like domains, a 21aa transmembrane segment, and a 105aa cytoplasmic domain with one immunotyrosine activation motif (ITAM) and two immunotyrosine inhibitory motifs (ITIMs). Mouse FCRL5 contains only five Ig-like domains in its ECD. It shares 49% aa sequence identity with human FCRL5 within common regions. Alternate splicing of human FCRL5 generates isoforms that consist of approximately the first one, six, or eight Ig-like domains. FCRL5 expression is restricted to mature B lineage cells in lymphoid tissues and blood. Its ligation inhibits signaling through the B cell antigen receptor. Epstein-Barr virus transformation of B cells induces the upregulation of surface FCRL5 by a direct effect of its EBNA2 protein on FCRL5 gene transcription. The FCRL5 gene maps to the 1q21 chromosomal locus, a common site of rearrangements in B cell malignancies, and the FCRL5 protein is preferentially expressed in cell lines with 1q21 abnormalities. FCRL5 is upregulated on tumor cells in some types of B cell malignancies. In addition, soluble FCRL5 is elevated in the serum of many B cell leukemia patients.

Product Categories/Family for FCRLA active protein

Molecular Biology; MB-Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 296434268
• NCBI GeneID: 84824
• NCBI Accession #: NP_001171801.1
• NCBI GenBank Nucleotide #: NM_001184872.1
• UniProt Accession #: Q7L513; Q5VXA1; Q5VXA2; Q5VXA3; Q5VXA4; Q5VXB0; Q8NEW4; Q8WXH3; Q96PC6; Q96PJ0; Q96PJ1; A0N0M1
• Molecular Weight: 91. 5kD
• NCBI Official Full Name: Fc receptor-like A isoform 5
• NCBI Official Synonym Full Names: Fc receptor-like A
• NCBI Official Symbol: FCRLA
• NCBI Official Synonym Symbols: FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2; RP11-474I16.5
• NCBI Protein Information: Fc receptor-like A; fc receptor-like protein; Fc receptor related protein X; fc receptor-related protein X; Fc receptor-like and mucin-like 1; fc receptor homolog expressed in B-cells; fc receptor-like and mucin-like protein 1; Fc receptor homolog expressed in B cells (FREB)
• UniProt Protein Name: Fc receptor-like A
• Protein Family: Fc receptor
• UniProt Gene Name: FCRLA
• UniProt Synonym Gene Names: FCRL; FCRL1; FCRLM1; FCRX; FREB; FcRX
• UniProt Entry Name: FCRLA_HUMAN

NCBI Description

This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

FCRLA iso9: May be implicated in B-cell differentiation and lymphomagenesis. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: cytoplasm; extracellular region

Biological Process: cell differentiation