Adrenocortical Dysplasia Homolog (ACD) Recombinant Protein | ACD recombinant protein

Recombinant Adrenocortical Dysplasia Homolog (ACD)

Cat. Num. AAA2086800

• Gene Names: ACD; PIP1; PTOP; TPP1; TINT1
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Adrenocortical Dysplasia Homolog (ACD); Recombinant Adrenocortical Dysplasia Homolog (ACD); TPP1; PIP1; PTOP; TINT1; TIN2 Interacting Protein 1; POT1 And TIN2 Organizing Protein; ACD recombinant protein

• Host: E Coli
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 544

• Applicable Applications for ACD recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Fragment: Glu244~Pro432
• Tag: N-terminal His-tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Source Note: Prokaryotic expression
• Organism Species: Human
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Isoelectric Point: 4.6
• Subcellular Location: Chromosome. Nucleus. Telomere.
• Usage: Reconstitute in PBS or others.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for ACD recombinant protein

Recombinant Protein

NCBI and Uniprot Product Information

• NCBI GI #: 130978956
• NCBI GeneID: 65057
• NCBI Accession #: NP_001075955.1
• NCBI GenBank Nucleotide #: NM_001082486.1
• UniProt Accession #: Q96AP0; Q562H5; Q9H8F9
• Molecular Weight: 23.0kDa
• NCBI Official Full Name: adrenocortical dysplasia protein homolog isoform 1
• NCBI Official Synonym Full Names: ACD, shelterin complex subunit and telomerase recruitment factor
• NCBI Official Symbol: ACD
• NCBI Official Synonym Symbols: PIP1; PTOP; TPP1; TINT1
• NCBI Protein Information: adrenocortical dysplasia protein homolog
• UniProt Protein Name: Adrenocortical dysplasia protein homolog
• Protein Family: Adrenocortical dysplasia protein
• UniProt Gene Name: ACD
• UniProt Synonym Gene Names: PIP1; PTOP; TINT1; TPP1

NCBI Description

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]

Uniprot Description

ACD: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus

Molecular Function: protein binding; telomeric DNA binding

Biological Process: intracellular protein transport; negative regulation of telomere maintenance via telomerase; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protection from non-homologous end joining at telomere; telomere assembly; telomere capping; telomere maintenance; telomere maintenance via telomerase

Disease: Dyskeratosis Congenita, Autosomal Dominant 6