aggrecan ELISA Kit | ACAN elisa kit

Mouse Aggrecan core protein (ACAN) ELISA Kit

Cat. Num. AAA9323417

• Gene Names: Acan; Agc; cmd; Agc1; Cspg1
• Synonyms: aggrecan; Mouse Aggrecan core protein (ACAN) ELISA Kit; ACAN elisa kit

• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 3.12 ng/ml - 100 ng/ml
• Sensitivity: 1.0 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for ACAN elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of ACAN (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 116875858
• NCBI GeneID: 11595
• NCBI Accession #: NP_031450.2
• NCBI GenBank Nucleotide #: NM_007424.2
• UniProt Accession #: Q61282; Q64021; E9QLS9
• Molecular Weight: 221,941 Da
• NCBI Official Full Name: aggrecan core protein
• NCBI Official Synonym Full Names: aggrecan
• NCBI Official Symbol: Acan
• NCBI Official Synonym Symbols: Agc; cmd; Agc1; Cspg1
• NCBI Protein Information: aggrecan core protein; CSPCP; aggrecan 1; cartilage-specific proteoglycan core protein
• UniProt Protein Name: Aggrecan core protein
• Protein Family: Aggrecan core protein
• UniProt Gene Name: Acan
• UniProt Synonym Gene Names: Agc; Agc1; CSPCP
• UniProt Entry Name: PGCA_MOUSE

Uniprot Description

ACAN: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. Defects in ACAN are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK). Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. Defects in ACAN are the cause of spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN). A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. Defects in ACAN are the cause of osteochondritis dissecans short stature and early-onset osteoarthritis (OD). It is a type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. Belongs to the aggrecan/versican proteoglycan family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Extracellular matrix; Secreted, signal peptide; Secreted

Cellular Component: proteinaceous extracellular matrix; extracellular region; basement membrane

Molecular Function: protein binding; extracellular matrix structural constituent; metal ion binding; hyaluronic acid binding; calcium ion binding; carbohydrate binding

Biological Process: central nervous system development; collagen fibril organization; proteoglycan biosynthetic process; chondrocyte development; cell adhesion; negative regulation of cell migration; cartilage condensation