Abl interactor 1 (Abi1) Recombinant Protein | Abi1 recombinant protein
Recombinant Mouse Abl interactor 1 (Abi1)
Gene Names
Abi1; E3B1; NAP1; abi-1; Ssh3bp1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Abl interactor 1 (Abi1); Recombinant Mouse Abl interactor 1 (Abi1); Abi1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-481, full length protein
Sequence
AELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVAAQFSAQPHVNGGPLYSQNSISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
Sequence Length
480
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Abi1 recombinant protein
This protein has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42,548 Da
NCBI Official Full Name
abl interactor 1 isoform 1
NCBI Official Synonym Full Names
abl-interactor 1
NCBI Official Symbol
Abi1
NCBI Official Synonym Symbols
E3B1; NAP1; abi-1; Ssh3bp1
NCBI Protein Information
abl interactor 1
UniProt Protein Name
Abl interactor 1
Protein Family
UniProt Gene Name
Abi1
UniProt Synonym Gene Names
Abi-1; Eps8-binding protein
Uniprot Description
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Research Articles on Abi1
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Product Notes
The Abi1 abi1 (Catalog #AAA1408369) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-481, full length protein. The amino acid sequence is listed below: AELQMLLEEE IPSGKRALIE SYQNLTRVAD YCENNYIQAT DKRKALEETK AYTTQSLASV AYQINALANN VLQLLDIQAS QLRRMESSIN HISQTVDIHK EKVARREIGI LTTNKNTSRT HKIIAPANME RPVRYIRKPI DYTVLDDVGH GVKWLKAKHG NNQPARTGTL SRTNPPTQKP PSPPVSGRGT LGRNTPYKTL EPVKPPTVPN DYMTSPARLG SQHSPGRTAS LNQRPRTHSG SSGGSGSREN SGSSSIGIPI AVPTPSPPTA GPAAPGAAPG SQYGTMTRQI SRHNSTTSST SSGGYRRTPS VAAQFSAQPH VNGGPLYSQN SISVAPPPPP MPQLTPQIPL TGFVARVQEN IADSPTPPPP PPPDDIPMFD DSPPPPPPPP VDYEDEEAAV VQYSDPYADG DPAWAPKNYI EKVVAIYDYT KDKDDELSFK EGAIIYVIKK NDDGWFEGVC NRVTGLFPGN YVESIMHYTD. It is sometimes possible for the material contained within the vial of "Abl interactor 1 (Abi1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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