Rat ATP-binding cassette, sub-family C (CFTR/MRP) , member 6 ELISA Kit | ABCC6 elisa kit

Rat Multidrug resistance-associated protein 6, ABCC6 ELISA Kit

Cat. Num. AAA9338834

• Gene Names: Abcc6; Mrp6
• Reactivity: Rat
• Synonyms: ATP-binding cassette; sub-family C (CFTR/MRP); member 6; Rat Multidrug resistance-associated protein 6; ABCC6 ELISA Kit; Rat Multidrug resistance-associated protein 6 (ABCC6) ELISA kit; ABC34; ARA; EST349056; MLP1; MOATE; MRP6; PXE; PXE1; URG7; sub-family C; anthracycline resistance-associated protein; ABCC6 elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 13591916
• NCBI GeneID: 81642
• NCBI Accession #: NP_112275.1
• NCBI GenBank Nucleotide #: NM_031013.1
• UniProt Accession #: O88269
• Molecular Weight: 164,995 Da
• NCBI Official Full Name: multidrug resistance-associated protein 6
• NCBI Official Synonym Full Names: ATP-binding cassette, subfamily C (CFTR/MRP), member 6
• NCBI Official Symbol: Abcc6
• NCBI Official Synonym Symbols: Mrp6
• NCBI Protein Information: multidrug resistance-associated protein 6; MLP-1; MRP-like protein 1; ATP-binding cassette sub-family C member 6; liver multidrug resistance-associated protein 6; ATP-binding cassette, sub-family C (CFTR/MRP), member 6
• UniProt Protein Name: Multidrug resistance-associated protein 6
• Protein Family: ABC transporter C family
• UniProt Gene Name: Abcc6
• UniProt Synonym Gene Names: Mlp1; Mrp6; MLP-1
• UniProt Entry Name: MRP6_RAT

NCBI Description

human homolog acts as a Mg-ATP-dependent efflux pump that transports glutathione S-conjugates and mediates a low level of resistance to some anticancer agents [RGD, Feb 2006]

Uniprot Description

ABCC6: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE). PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE). Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2). GACI2 is a severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Membrane protein, integral; Transporter, ABC family; Hydrolase; Membrane protein, multi-pass; Transporter

Cellular Component: membrane; basolateral plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; nucleus; lateral plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATPase activity; ATP binding

Biological Process: metabolic process; transmembrane transport