Mouse Multidrug resistance-associated protein 6 ELISA Kit | Abcc6 elisa kit

Mouse Multidrug resistance-associated protein 6 ELISA Kit

Cat. Num. AAA2880209

• Gene Names: Abcc6; DCC; Mrp6; Abcc1b; dyscalc; Dyscalc1
• Reactivity: Mouse
• Synonyms: Multidrug resistance-associated protein 6; Mouse Multidrug resistance-associated protein 6 ELISA Kit; ATP-binding cassette sub-family C member 6; Abcc6; Mrp6; Abcc6 elisa kit

• Reactivity: Mouse
• Sequence Length: 1498

• Assay Type: Sandwich
• Detection Range: 78-5000 pg/mL
• Sensitivity: 39.9 pg/mL
• Intra-Assay CV: <=6.9%
• Inter-Assay CV: <=8.8%
• Recovery: 105%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 145275191
• NCBI GeneID: 27421
• NCBI Accession #: NP_061265.2
• NCBI GenBank Nucleotide #: NM_018795.2
• UniProt Accession #: Q9R1S7; Q80YB6; A2TAJ0; A2TAJ1; F8VPT2
• Molecular Weight: 164,857 Da
• NCBI Official Full Name: multidrug resistance-associated protein 6
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
• NCBI Official Symbol: Abcc6
• NCBI Official Synonym Symbols: DCC; Mrp6; Abcc1b; dyscalc; Dyscalc1
• NCBI Protein Information: multidrug resistance-associated protein 6
• UniProt Protein Name: Multidrug resistance-associated protein 6
• Protein Family: Multidrug resistance-associated protein
• UniProt Gene Name: Abcc6
• UniProt Synonym Gene Names: Mrp6
• UniProt Entry Name: MRP6_MOUSE

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein is unknown; however, a similar rat protein has been identified as the major canalicular bile salt export pump of liver. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCC6: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE). PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE). Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2). GACI2 is a severe autosomal recessive disorder characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. The disorder is often fatal within the first 6 months of life because of myocardial ischemia resulting in refractory heart failure. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Transporter, ABC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral; Hydrolase

Cellular Component: apical plasma membrane; integral to membrane; lateral plasma membrane; membrane; nucleus; plasma membrane

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; nucleotide binding

Biological Process: transmembrane transport; transport