Alpha-2-macroglobulin Recombinant Protein | A2MG recombinant protein

Recombinant Rat Alpha-2-macroglobulin

Cat. Num. AAA9422152

• Gene Names: A2m; Mam; A2m1; A2mb; A2maa; A2MAC1
• Reactivity: Rat
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Alpha-2-macroglobulin; Recombinant Rat Alpha-2-macroglobulin; A2MG recombinant protein

• Host: Yeast
• Reactivity: Rat
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Partial, 620-750aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for A2MG recombinant protein

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme rains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

NCBI and Uniprot Product Information

• NCBI GI #: 158138551
• NCBI GeneID: 24153
• NCBI Accession #: NP_036620.2
• NCBI GenBank Nucleotide #: NM_012488.2
• UniProt Accession #: P06238; Q4FZY3
• Molecular Weight: 16.9kD
• NCBI Official Full Name: alpha-2-macroglobulin
• NCBI Official Synonym Full Names: alpha-2-macroglobulin
• NCBI Official Symbol: A2m
• NCBI Official Synonym Symbols: Mam; A2m1; A2mb; A2maa; A2MAC1
• NCBI Protein Information: alpha-2-macroglobulin
• UniProt Protein Name: Alpha-2-macroglobulin
• Protein Family: Alpha-2-macroglobulin
• UniProt Gene Name: A2m
• UniProt Synonym Gene Names: A2m1; Alpha-2-M

NCBI Description

plays a role in acute phase response; activated form induces a decrease in N-methyl-D-aspartate (NMDA) mediated calcium signaling [RGD, Feb 2006]

Uniprot Description

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.