Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Pannexin-1 (PANX1) Standard Curve.)
Human Pannexin-1 (PANX1) ELISA Kit | PANX1 elisa kit
Human Pannexin-1 (PANX1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Pannexin-1 (PANX1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Pannexin-1 (PANX1) Standard Curve.)
Background: Pannexin 1 belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. The deduced 48-kD protein contains 4 transmembrane domains and cytoplasmic N and C termini. Northern blot analysis detected Panx1 expression in rat eye, thyroid, prostate, kidney, liver, and central nervous system. In situ hybridization showed Pnx1 expression in several brain regions, including cortex, striatum, olfactory bulb, hippocampus, thalamus, and cerebellum.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
Uniprot Description
PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: endoplasmic reticulum membrane; protein complex; membrane; endoplasmic reticulum; integral to membrane; plasma membrane; gap junction
Molecular Function: actin filament binding; protease binding; leak channel activity; protein heterodimerization activity; calcium channel activity; gap junction hemi-channel activity; receptor binding
Biological Process: positive regulation of interleukin-1 alpha secretion; synaptic transmission; calcium ion transport; innate immune response; positive regulation of interleukin-1 beta secretion; response to ATP; cation transport
Research Articles on PANX1
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Product Notes
The Human PANX1 panx1 (Catalog #AAA9714973) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714973 ELISA Kit recognizes Human PANX1. It is sometimes possible for the material contained within the vial of "Pannexin-1 (PANX1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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