Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Phosphotidylinositol phosphatase PTPRQ (PTPRQ) Standard Curve.)
Human Phosphotidylinositol Phosphatase PTPRQ (PTPRQ) ELISA Kit | PTPRQ elisa kit
Human Phosphotidylinositol Phosphatase PTPRQ (PTPRQ) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Phosphotidylinositol phosphatase PTPRQ (PTPRQ) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Phosphotidylinositol phosphatase PTPRQ (PTPRQ) Standard Curve.)
Background: PTPRQ belongs to the type III receptor-like protein-tyrosine phosphatase (PTPase) family. PTPRQ has low activity against phosphotyrosine, but is active against phosphatidylinositol phosphates that are involved in regulation of survival, proliferation, and subcellular architecture. The genomic region containing nt 391..910 of this sequence are inverted in the human reference genome (build 37). This portion of the RefSeq is inferred based on alignments of rat and mouse transcripts, and is supported by the human Celera assembly. In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.
NCBI and Uniprot Product Information
Uniprot Description
PTPRQ: Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells. Defects in PTPRQ are the cause of deafness autosomal recessive type 84 (DFNB84). DFNB84 is a form of non- syndromic deafness characterized by progressive, sensorineural hearing loss and vestibular dysfunction. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Protein type: EC 3.1.3.48; Membrane protein, integral; Phosphatase, lipid; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 12q21.31
Cellular Component: integral component of membrane
Molecular Function: protein tyrosine phosphatase activity
Biological Process: cell differentiation; inner ear morphogenesis; phosphatidylinositol dephosphorylation; regulation of fat cell differentiation
Disease: Deafness, Autosomal Dominant 73; Deafness, Autosomal Recessive 84a
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Product Notes
The Human PTPRQ ptprq (Catalog #AAA9714710) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714710 ELISA Kit recognizes Human PTPRQ. It is sometimes possible for the material contained within the vial of "Phosphotidylinositol Phosphatase PTPRQ (PTPRQ), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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