Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Transient receptor potential cation channel subfamily A member 1 (TRPA1) Standard Curve.)
Human Transient Receptor Potential Cation Channel Subfamily A Member 1 (TRPA1) ELISA Kit | TRPA1 elisa kit
Human Transient Receptor Potential Cation Channel Subfamily A Member 1 (TRPA1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Transient receptor potential cation channel subfamily A member 1 (TRPA1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Transient receptor potential cation channel subfamily A member 1 (TRPA1) Standard Curve.)
Background: TRPA1 is a member of the transient receptor potential channel family. TRPA1, contains 14 N-terminal ankyrin repeats and is believed to function as a mechanical stress sensor. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. Recent studies indicate that TRPA1 is activated by a number reactive compounds (allyl isothiocyanate, cinnamaldehyde, farnesyl thiosalicylic acid, Nicotine and its structural analogues formalin, hydrogen peroxide, 4-hydroxynonenal, and acrolein) and considered as a 'chemosensor' in the body. TRPA1 is considered as an attractive pain target based on the fact that TRPA1 knockout mice showed near complete attenuation of formalin-induced pain behaviors.
NCBI and Uniprot Product Information
NCBI Description
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
Uniprot Description
TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: stereocilium bundle; integral to plasma membrane; plasma membrane
Molecular Function: channel activity; calcium channel activity
Biological Process: response to drug; detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; response to hydrogen peroxide; response to pain; ion transport; thermoception; response to cold; transmembrane transport
Disease: Episodic Pain Syndrome, Familial, 1
Research Articles on TRPA1
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Product Notes
The Human TRPA1 trpa1 (Catalog #AAA9713801) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9713801 ELISA Kit recognizes Human TRPA1. It is sometimes possible for the material contained within the vial of "Transient Receptor Potential Cation Channel Subfamily A Member 1 (TRPA1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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