Rabbit anti-Human CB2 Polyclonal Antibody | anti-CB2 antibody

CB2 Polyclonal Antibody

Cat. Num. AAA9701601

• Gene Names: CNR2; CB2; CX5; CB-2
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CB2; Polyclonal Antibody; CB2 Polyclonal Antibody; Rabbit Anti-CB2 Polyclonal Antibody; CNR2; Cannabinoid receptor 2; CB-2; hCB2; CX5; anti-CB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CB2 Polyclonal Antibody detects endogenous levels of CB2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; PBS Containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 360

• Applicable Applications for anti-CB2 antibody: Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000; ELISA: 1:5000; Optimal working dilutions should be determined experimentally by the investigator.; Not tested in other applications.
• Preparation and Storage: Stable at -20°C from date of receipt.; For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.; Aliquot to avoid repeated freezing and thawing.

Western Blot (WB)

(Fig. Western Blot analysis of various cells using CB2 Polyclonal Antibody.)

Related Product Information for anti-CB2 antibody

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by CNR2 and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.

NCBI and Uniprot Product Information

• NCBI GI #: 4502929
• NCBI GeneID: 1269
• NCBI Accession #: NP_001832.1
• NCBI GenBank Nucleotide #: NP_001832.1
• UniProt Accession #: P34972
• NCBI Official Full Name: cannabinoid receptor 2
• NCBI Official Synonym Full Names: cannabinoid receptor 2
• NCBI Official Symbol: CNR2
• NCBI Official Synonym Symbols: CB2; CX5; CB-2
• NCBI Protein Information: cannabinoid receptor 2
• UniProt Protein Name: Cannabinoid receptor 2
• UniProt Gene Name: CNR2
• UniProt Synonym Gene Names: CB2A; CB2B; CB-2; CB2; hCB2
• UniProt Entry Name: CNR2_HUMAN

NCBI Description

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

CNR2: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extrinsic to internal side of plasma membrane; integral to plasma membrane; dendrite; plasma membrane; perikaryon

Molecular Function: cannabinoid receptor activity

Biological Process: negative regulation of mast cell activation; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of nitric-oxide synthase activity; negative regulation of inflammatory response; response to amphetamine; response to lipopolysaccharide; immune response; negative regulation of action potential; negative regulation of synaptic transmission, GABAergic; inflammatory response; sensory perception of pain