SDS-PAGE
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor protein (HBEGF) Active Protein | HBEGF active protein
Recombinant Human Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor protein (HBEGF) (Active)
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
Uniprot Description
HBEGF: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component: cell surface; extracellular region; extracellular space; integral to plasma membrane; plasma membrane
Molecular Function: epidermal growth factor receptor binding; growth factor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; MAPKKK cascade; muscle development; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; regulation of phosphoinositide 3-kinase cascade; signal transduction
Research Articles on HBEGF
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Product Notes
The HBEGF hbegf (Catalog #AAA969383) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 63-148aa. The amino acid sequence is listed below: DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL. It is sometimes possible for the material contained within the vial of "Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor protein (HBEGF), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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