Lysozyme C Recombinant Protein | LYZ recombinant protein

Recombinant Human Lysozyme C

Cat. Num. AAA964010

• Gene Names: LYZ; LZM; LYZF1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Lysozyme C; Recombinant Human Lysozyme C; 1; 4-beta-N-acetylmuramidase C; LYZ recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 19-148aa; Full Length
• Sequence: KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV
• Sequence Length: 148

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for LYZ recombinant protein

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Product Categories/Family for LYZ recombinant protein

Tags & Cell Markers

References

Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae.Castanon M.J., Spevak W., Adolf G.R., Chlebowicz-Sledziewska E., Sledziewski A.Gene 66:223-234(1988) Cloning the human lysozyme cDNA inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells.Chung L.P., Keshav S., Gordon S.Proc. Natl. Acad. Sci. U.S.A. 85:6227-6231(1988) Human lysozyme sequencing of a cDNA, and expression and secretion by Saccharomyces cerevisiae.Yoshimura K., Toibana A., Nakahama K.Biochem. Biophys. Res. Commun. 150:794-801(1988) The human lysozyme gene. Sequence organization and chromosomal localization.Peters C.W.B., Kruse U., Pollwein R., Grzeschik K.H., Sippel A.E.Eur. J. Biochem. 182:507-516(1989) The cloning, sequencing and analysis of Chinese human lysozyme gene cDNA amplified with RT-PCR from human placental total RNA.Huang B., Zhao C., Lei X., Cai L.Sheng Wu Hua Hsueh Tsa Chih 9:269-273(1993) Primary structure of lysozymes from man and goose.Canfield R.E., Kammerman S., Sobel H.H., Morgan F.J.Nature New Biol. 232:16-17(1971) A Val-Val sequence found in a human monocytic leukemia lysozyme.Thomsen J., Lund E.H., Kristiansen K., Brunfeldt K., Malmquist J.FEBS Lett. 22:34-36(1972) Human milk lysozyme unpublished data concerning the establishment of the complete primary structure; comparison with lysozymes of various origins.Jolles J., Jolles P.Helv. Chim. Acta 54:2668-2675(1971) Comparison between human and bird lysozymes note concerning the previously observed deletion.Jolles J., Jolles P.FEBS Lett. 22:31-33(1972) Indication of possible post-translational formation of disulphide bonds in the beta-sheet domain of human lysozyme.Kanaya E., Ishihara K., Tsunasawa S., Nokihara K., Kikuchi M.Biochem. J. 292:469-476(1993) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) The high resolution X-ray study of human. lysozyme a preliminary analysis.Banyard S.H., Blake C.C.F., Swan I.D.A.(In) Osserman E.F., Canfield R.E., Beychok S. (eds.) ;Lysozyme, pp.71-79, Academic Press, New York (1974) Refinement of human lysozyme at 1.5-A resolution analysis of non-bonded and hydrogen-bond interactions.Artymiuk P.J., Blake C.C.F.J. Mol. Biol. 152:737-762(1981) X-ray studies of water in crystals of lysozyme.Blake C.C.F., Pulford W.C.A., Artymiuk P.J.J. Mol. Biol. 167:693-723(1983) The crystal structure of a mutant human lysozyme C77/95A with increased secretion efficiency in yeast.Inaka K., Taniyama Y., Kikuchi M., Morikawa K., Matsushima M.J. Biol. Chem. 266:12599-12603(1991) Structures of monoclinic lysozyme iodide at 1.6 A and of triclinic lysozyme nitrate at 1.1 A.Steinrauf L.K.Acta Crystallogr. D 54:767-780(1998) 1H NMR studies of human lysozyme spectral assignment and comparison with hen lysozyme.Redfield C., Dobson C.M.Biochemistry 29:7201-7214(1990) 1H and 15N NMR study of human lysozyme.Ohkubo T., Taniyama Y., Kikuchi M.J. Biochem. 110:1022-1029(1991) Human lysozyme gene mutations cause hereditary systemic amyloidosis.Pepy M.B., Hawkins P.N., Booth D.R., Vigushin D.M., Tennent G.A., Soutar A.K., Totty N., Nguyen O., Blake C.C.F., Terry C.J., Feest T.G., Zalin A.M., Hsuan J.J.Nature 362:553-557(1993)

NCBI and Uniprot Product Information

• NCBI GI #: 4557894
• NCBI GeneID: 4069
• NCBI Accession #: NP_000230.1
• NCBI GenBank Nucleotide #: NM_000239.2
• UniProt Accession #: P61626; P00695; Q13170; Q9UCF8
• Molecular Weight: 30.7 kDa
• NCBI Official Full Name: lysozyme C
• NCBI Official Synonym Full Names: lysozyme
• NCBI Official Symbol: LYZ
• NCBI Official Synonym Symbols: LZM; LYZF1
• NCBI Protein Information: lysozyme C
• UniProt Protein Name: Lysozyme C
• Protein Family: Lysozyme
• UniProt Gene Name: LYZ
• UniProt Synonym Gene Names: LZM
• UniProt Entry Name: LYSC_HUMAN

NCBI Description

This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

Uniprot Description

LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family.

Protein type: Endoplasmic reticulum; Hydrolase; EC 3.2.1.17; Secreted; Vesicle; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular region; extracellular space

Molecular Function: identical protein binding; lysozyme activity

Biological Process: cellular protein metabolic process; cytolysis; defense response to bacterium; inflammatory response; retinal homeostasis

Disease: Amyloidosis, Familial Visceral