Rabbit anti-Human, Mouse TBCB Polyclonal Antibody | anti-TBCB antibody
TBCB Antibody
Gene Names
TBCB; CG22; CKAP1; CKAPI
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
TBCB; Polyclonal Antibody; TBCB Antibody; CG22; CKAPI; Cytoskeleton associated protein 1; Cytoskeleton associated protein CKAPI; Cytoskeleton-associated protein 1; Cytoskeleton-associated protein CKAPI; Tbcb; TBCB_HUMAN; Tubulin folding cofactor B; Tubulin specific chaperone B; Tubulin-folding cofactor B; Tubulin-specific chaperone B; anti-TBCB antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
TBCB Antibody detects endogenous levels of TBCB.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-TBCB antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human TBCB.
Conjugation
Unconjugated
Similarity
Belongs to the TBCB family.
Post Translational Modifications
Phosphorylation by PAK1 is required for normal function.Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.
Subunit Structure
Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers (By similarity). Interacts with GAN. Interacts with DCTN1.
Tissue Specificity
Found in most tissues.
Function
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).
Note
Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-TBCB antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
244
NCBI Official Full Name
Tubulin-folding cofactor B
NCBI Official Synonym Full Names
tubulin folding cofactor B
NCBI Official Symbol
TBCB
NCBI Official Synonym Symbols
CG22; CKAP1; CKAPI
NCBI Protein Information
tubulin-folding cofactor B; tubulin-specific chaperone B; cytoskeleton associated protein 1; cytoskeleton-associated protein CKAPI
UniProt Protein Name
Tubulin-folding cofactor B
UniProt Gene Name
TBCB
UniProt Synonym Gene Names
CG22; CKAP1
UniProt Entry Name
TBCB_HUMAN
Uniprot Description
TBCB: a cytoskeletal protein that binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.
Protein type: Motility/polarity/chemotaxis; Chaperone; Cytoskeletal
Chromosomal Location of Human Ortholog: 19q13.11-q13.12
Cellular Component: microtubule cytoskeleton; nucleoplasm; microtubule; cytoplasm
Molecular Function: protein binding
Biological Process: nervous system development; 'de novo' posttranslational protein folding; cellular protein metabolic process; cell differentiation
Research Articles on TBCB
Similar Products
Product Notes
The TBCB tbcb (Catalog #AAA9631378) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TBCB Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TBCB can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the TBCB tbcb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TBCB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
