Rabbit anti-Human, Mouse WDR45B Polyclonal Antibody | anti-WDR45B antibody
WDR45B Antibody
Gene Names
WDR45B; WIPI3; WDR45L; WIPI-3
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
WDR45B; Polyclonal Antibody; WDR45B Antibody; WD repeat domain phosphoinositide-interacting protein 3; WD repeat protein 45 like; WD repeat-containing protein 45-like; WDR4 like; WDR45 like protein; WDR45-like protein; wdr45l; WIPI 3; WIPI-3; WIPI3; WIPI3_HUMAN; WIPI49 like protein; WIPI49-like protein; anti-WDR45B antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
WDR45B Antibody detects endogenous levels of WDR45B.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-WDR45B antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human WDR45B.
Conjugation
Unconjugated
Similarity
Belongs to the WD repeat SVP1 family.
Subunit Structure
Interacts with the TSC1-TSC2 complex; stimulated upon starvation. Interacts with RB1CC1.
Tissue Specificity
Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers.
Function
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2. In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-WDR45B antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,122 Da
NCBI Official Full Name
WD repeat domain phosphoinositide-interacting protein 3
NCBI Official Synonym Full Names
WD repeat domain 45B
NCBI Official Symbol
WDR45B
NCBI Official Synonym Symbols
WIPI3; WDR45L; WIPI-3
NCBI Protein Information
WD repeat domain phosphoinositide-interacting protein 3; WDR45-like protein; WIPI49-like protein; WD repeat protein 45-like; WD repeat-containing protein 45B; WD repeat-containing protein 45-like
UniProt Protein Name
WD repeat domain phosphoinositide-interacting protein 3
Protein Family
UniProt Gene Name
WDR45B
UniProt Synonym Gene Names
WDR45L; WIPI3; WIPI-3
UniProt Entry Name
WIPI3_HUMAN
NCBI Description
This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Tissue specificity: Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers. Ref.4
Sequence similarities: Belongs to the WD repeat SVP1 family.Contains 2 WD repeats.
Sequence caution: The sequence AAC72952.1 differs from that shown. Reason: Erroneous initiation.
Similar Products
Product Notes
The WDR45B wdr45b (Catalog #AAA9631194) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The WDR45B Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's WDR45B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the WDR45B wdr45b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WDR45B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
