Rabbit anti-Human, Mouse PLEKHH2 Polyclonal Antibody | anti-PLEKHH2 antibody

PLEKHH2 Antibody

Cat. Num. AAA9631117

• Gene Names: PLEKHH2; PLEKHH1L
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: PLEKHH2; Polyclonal Antibody; PLEKHH2 Antibody; KIAA2028; PKHH2_HUMAN; Pleckstrin homology domain containing family H member 2; Pleckstrin homology domain-containing family H member 2; Pleckstrin homology MyTH4 and FERM domain containing H2; PLEKHH1L; Plekhh2; PLEKHH2 pleckstrin homology domain containing; family H (with MyTH4 domain) member 2; anti-PLEKHH2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PLEKHH2 Antibody detects endogenous levels of PLEKHH2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PLEKHH2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human PLEKHH2.
• Conjugation: Unconjugated
• Subunit Structure: Self-associates. Interacts with TGFB1I1 (By similarity).
• Tissue Specificity: Kidney. Reduced expression in patients with focal segmental glomerulosclerosis.
• Function: In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.
• Note: Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-PLEKHH2 antibody

Cytoplasm; Cytoskeleton; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cell projection; Lamellipodium; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 217416392
• NCBI GeneID: 130271
• NCBI Accession #: NP_742066.2
• NCBI GenBank Nucleotide #: NM_172069.3
• UniProt Accession #: Q8IVE3; Q5JPJ6; Q6P4Q1; Q8N3Q3
• Molecular Weight: 89,122 Da
• NCBI Official Full Name: pleckstrin homology domain-containing family H member 2
• NCBI Official Synonym Full Names: pleckstrin homology, MyTH4 and FERM domain containing H2
• NCBI Official Symbol: PLEKHH2
• NCBI Official Synonym Symbols: PLEKHH1L
• NCBI Protein Information: pleckstrin homology domain-containing family H member 2
• UniProt Protein Name: Pleckstrin homology domain-containing family H member 2
• Protein Family: Pleckstrin homology domain-containing family
• UniProt Gene Name: PLEKHH2
• UniProt Synonym Gene Names: KIAA2028

Uniprot Description

PLEKHH2: 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cortical actin cytoskeleton; cytoplasm; lamellipodium; plasma membrane

Molecular Function: actin binding; identical protein binding; protein binding

Biological Process: negative regulation of actin filament depolymerization