Rabbit anti-Human, Mouse PAPD7 Polyclonal Antibody | anti-PAPD7 antibody

PAPD7 Antibody

Cat. Num. AAA9631064

• Gene Names: PAPD7; LAK1; POLK; POLS; TRF4; LAK-1; TRF41; TRF4-1; TUTASE5
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: PAPD7; Polyclonal Antibody; PAPD7 Antibody; DNA polymerase kappa; DNA polymerase sigma; LAK 1; LAK-1; LAK1; OTTHUMP00000115520; PAP associated domain containing 7; PAP-associated domain-containing protein 7; Papd7; PAPD7_HUMAN; POLK; POLS; Polymerase (DNA directed) sigma; Polymerase DNA Directed Sigma; Terminal uridylyltransferase 5; Topoisomerase related function protein 4 1; Topoisomerase-related function protein 4-1; TRF4 1; TRF4; TRF4-1; TRF41; TUTase 5; TUTASE5; anti-PAPD7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PAPD7 Antibody detects endogenous levels of PAPD7.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PAPD7 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human PAPD7.
• Conjugation: Unconjugated
• Similarity: Belongs to the DNA polymerase type-B-like family.
• Subunit Structure: Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.
• Function: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.
• Note: Excluded from nucleolus, weak staining detected in the cytoplasm.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-PAPD7 antibody

Cytoplasm; Nucleus; Nucleoplasm; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 284507291
• NCBI GeneID: 11044
• NCBI Accession #: NP_008930.1
• NCBI GenBank Nucleotide #: NM_006999
• UniProt Accession #: Q5XG87; O43289; Q17RZ1; Q9Y6C1; A8K1E2; M1JCE6
• Molecular Weight: 59,874 Da
• NCBI Official Full Name: Homo sapiens PAP associated domain containing 7 (PAPD7), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: PAP associated domain containing 7
• NCBI Official Symbol: PAPD7
• NCBI Official Synonym Symbols: LAK1; POLK; POLS; TRF4; LAK-1; TRF41; TRF4-1; TUTASE5
• NCBI Protein Information: non-canonical poly(A) RNA polymerase PAPD7; non-canonical poly(A) RNA polymerase PAPD7; DNA polymerase kappa; DNA polymerase sigma; PAP-associated domain-containing protein 7; TRAMP-like complex polyadenylate polymerase; TUTase 5; polymerase (DNA directed
• UniProt Protein Name: Non-canonical poly(A) RNA polymerase PAPD7
• UniProt Gene Name: PAPD7
• UniProt Synonym Gene Names: POLS; TRF4; TUTase 5; TRF4-1
• UniProt Entry Name: PAPD7_HUMAN

NCBI Description

The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]

Uniprot Description

POLS: DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation. Belongs to the DNA polymerase type-B-like family.

Protein type: EC 2.7.7.19; DNA repair, damage; DNA replication; Transferase

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: polynucleotide adenylyltransferase activity; DNA binding; SMC protein binding; metal ion binding; DNA-directed DNA polymerase activity

Biological Process: response to drug; cell division; mitotic chromosome condensation; double-strand break repair; sister chromatid cohesion