Rabbit ATP4A Polyclonal Antibody | anti-ATP4A antibody

ATP4A Antibody

Cat. Num. AAA9630485

• Gene Names: ATP4A; ATP6A
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ATP4A; Polyclonal Antibody; ATP4A Antibody; Atp4a; ATP4A_HUMAN; ATP6A; ATPase H+/K+ exchanging alpha polypeptide; ATPase H+/K+ transporting alpha polypeptide; Gastric H K ATPase alpha subunit; Gastric H K ATPase catalytic subunit; Gastric H(+)/K(+) ATPase subunit alpha; Gastric H+/K+ ATPase alpha subunit; Gastric hydrogen potassium ATPase; H(+) K(+) ATPase alpha subunit; Potassium-transporting ATPase alpha chain 1; Proton pump; anti-ATP4A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ATP4A Antibody detects endogenous levels of ATP4A.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ATP4A antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human ATP4A.
• Conjugation: Unconjugated
• Similarity: Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IIC subfamily.
• Subunit Structure: Composed of two subunits: alpha (catalytic) and beta.
• Tissue Specificity: Found in gastric mucosa.
• Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ATP4A antibody

Cell membrane; Multi-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 51944966
• NCBI GeneID: 495
• NCBI Accession #: NP_000695.2
• NCBI GenBank Nucleotide #: NM_000704.2
• UniProt Accession #: P20648; O00738
• Molecular Weight: 114,119 Da
• NCBI Official Full Name: potassium-transporting ATPase alpha chain 1
• NCBI Official Synonym Full Names: ATPase H+/K+ transporting alpha subunit
• NCBI Official Symbol: ATP4A
• NCBI Official Synonym Symbols: ATP6A
• NCBI Protein Information: potassium-transporting ATPase alpha chain 1
• UniProt Protein Name: Potassium-transporting ATPase alpha chain 1
• Protein Family: Potassium-transporting ATPase
• UniProt Gene Name: ATP4A

NCBI Description

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

Uniprot Description

ATP4A: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Protein type: EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: extracellular space; integral component of plasma membrane; plasma membrane

Molecular Function: ATP binding; hydrogen:potassium-exchanging ATPase activity; magnesium ion binding; sodium:potassium-exchanging ATPase activity

Biological Process: ATP hydrolysis coupled proton transport; establishment or maintenance of transmembrane electrochemical gradient; potassium ion transport; sodium ion transport; transport