Rabbit anti-Human SYNE4 Polyclonal Antibody | anti-SYNE4 antibody
SYNE4 Antibody
Gene Names
SYNE4; Nesp4; C19orf46
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SYNE4; Polyclonal Antibody; SYNE4 Antibody; Chromosome 19 open reading frame 46; FLJ36445; Hypothetical protein LOC163183; Nesp4; Nesprin 4; Nuclear envelope spectrin repeat protein 4; Spectrin repeat containing nuclear envelope family member 4; anti-SYNE4 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SYNE4 Antibody detects endogenous levels of SYNE4.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SYNE4 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human SYNE4.
Conjugation
Unconjugated
Similarity
The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. Belongs to the nesprin family.
Post Translational Modifications
The disulfid bond with SUN1 or SUN2 is required for stability of the respective LINC complex under tensile forces.
Subunit Structure
Core component of LINC complexes which are composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents can give rise to specific assemblies (By similarity). Probably part of a SUN1-containing LINC complex. Interacts with kinesins KIF5B and KLC1 (By similarity).
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).
Note
Localization at the nucleus outer membrane requires the presence of SUN1.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SYNE4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43,512 Da
NCBI Official Full Name
nesprin-4
NCBI Official Synonym Full Names
spectrin repeat containing, nuclear envelope family member 4
NCBI Official Symbol
SYNE4
NCBI Official Synonym Symbols
Nesp4; C19orf46
NCBI Protein Information
nesprin-4; nuclear envelope spectrin repeat protein 4
UniProt Protein Name
Nesprin-4
Protein Family
UniProt Gene Name
SYNE4
UniProt Synonym Gene Names
C19orf46
UniProt Entry Name
SYNE4_HUMAN
Similar Products
Product Notes
The SYNE4 syne4 (Catalog #AAA9630358) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SYNE4 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SYNE4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SYNE4 syne4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SYNE4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
