Rabbit KRTCAP2 Polyclonal Antibody | anti-KRTCAP2 antibody

KRTCAP2 Antibody

Cat. Num. AAA9630292

• Gene Names: KRTCAP2; KCP2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: KRTCAP2; Polyclonal Antibody; KRTCAP2 Antibody; KCP-2; KCP2; Keratinocyte-associated protein 2; KTAP2_HUMAN; anti-KRTCAP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: KRTCAP2 Antibody detects endogenous levels of KRTCAP2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-KRTCAP2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human KRTCAP2.
• Conjugation: Unconjugated
• Similarity: Belongs to the KRTCAP2 family.
• Subunit Structure: Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity). Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex.
• Tissue Specificity: Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes and dermal fibroblasts.
• Function: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-KRTCAP2 antibody

Endoplasmic reticulum; Endoplasmic reticulum membrane; Multi-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 27777661
• NCBI GeneID: 200185
• NCBI Accession #: NP_776251.1
• NCBI GenBank Nucleotide #: NM_173852.3
• UniProt Accession #: Q8N6L1; Q6PG45; Q86XW2; Q8IWS4; B2R4Q1
• Molecular Weight: 14,679 Da
• NCBI Official Full Name: keratinocyte-associated protein 2
• NCBI Official Synonym Full Names: keratinocyte associated protein 2
• NCBI Official Symbol: KRTCAP2
• NCBI Official Synonym Symbols: KCP2
• NCBI Protein Information: keratinocyte-associated protein 2; KCP-2; keratinocytes associated protein 2
• UniProt Protein Name: Keratinocyte-associated protein 2
• Protein Family: Keratinocyte-associated protein
• UniProt Gene Name: KRTCAP2
• UniProt Synonym Gene Names: KCP2; KCP-2
• UniProt Entry Name: KTAP2_HUMAN