Rabbit anti-Human INCA1 Polyclonal Antibody | anti-INCA1 antibody
INCA1 Antibody
Gene Names
INCA1; HSD45
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
INCA1; Polyclonal Antibody; INCA1 Antibody; HSD45; Inca1; INCA1_HUMAN; Inhibitor of CDK cyclin A1 interacting protein 1; Inhibitor of CDK interacting with cyclin A1; MGC148150; MGC148151; Protein INCA1; anti-INCA1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
INCA1 Antibody detects endogenous levels of INCA1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-INCA1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human INCA1.
Conjugation
Unconjugated
Similarity
Belongs to the INCA family.
Post Translational Modifications
Phosphorylated when part of a complex with CCNA1 and CDK2. Strongly phosphorylated by CDK2 on its C-terminal region spanning amino acid 149-221. Less intensively phosphorylated by CDK2 on its first 75 amino acid residues.
Subunit Structure
Interacts with CCNA1. Interacts with CCNA2, CCNB1 and CCNE1. Found in a complex with CCNA1 and CDK2. Interacts with ZNF16; the interaction inhibits INCA1 activity and induces the cell cycle process. Interacts with SPACA9. Interacts with the CCNA1/CDK2 complex. Interacts with ING5, DAZAP2, RNF26, USP15, SPOUT1, DPH7, TRIM26 and RAB5C.
Tissue Specificity
Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors. Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells.
Function
Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,216 Da
NCBI Official Full Name
protein INCA1 isoform 2
NCBI Official Synonym Full Names
inhibitor of CDK, cyclin A1 interacting protein 1
NCBI Official Symbol
INCA1
NCBI Official Synonym Symbols
HSD45
NCBI Protein Information
protein INCA1
UniProt Protein Name
Protein INCA1
Protein Family
UniProt Gene Name
INCA1
UniProt Entry Name
INCA1_HUMAN
Uniprot Description
INCA1: Belongs to the INCA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: cytoplasm; nucleus
Molecular Function: cyclin-dependent protein kinase inhibitor activity; cyclin binding; protein binding
Biological Process: negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity
Research Articles on INCA1
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Product Notes
The INCA1 inca1 (Catalog #AAA9630264) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INCA1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's INCA1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the INCA1 inca1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INCA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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