Rabbit ABCB9 Polyclonal Antibody | anti-ABCB9 antibody

ABCB9 Antibody

Cat. Num. AAA9630062

• Gene Names: ABCB9; TAPL; EST122234
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ABCB9; Polyclonal Antibody; ABCB9 Antibody; ABC transporter 9 protein; ABCB 9; ATP binding cassette sub family B (MDR/TAP) member 9; ATP binding cassette sub family B member 9 precursor; ATP binding cassette transporter 9; EST122234; hABCB9; KIAA1520; TAP like protein; TAPL; anti-ABCB9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ABCB9 Antibody detects endogenous levels of ABCB9.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ABCB9 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human ABCB9.
• Conjugation: Unconjugated
• Similarity: The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3. A. 1. 209) subfamily.
• Subunit Structure: Homodimer.
• Tissue Specificity: Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.
• Function: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
• Note: May be located in membrane rafts.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ABCB9 antibody

Lysosome membrane; Multi-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 22095458
• NCBI GeneID: 23457
• UniProt Accession #: Q9NP78; Q5W9G7; Q769F3; Q769F4; Q96AB1; Q9P208; B4E2J0
• Molecular Weight: 766
• NCBI Official Full Name: ATP-binding cassette sub-family B member 9
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family B (MDR/TAP), member 9
• NCBI Official Symbol: ABCB9
• NCBI Official Synonym Symbols: TAPL; EST122234
• NCBI Protein Information: ATP-binding cassette sub-family B member 9; TAP-like protein; ABC transporter 9 protein
• UniProt Protein Name: ATP-binding cassette sub-family B member 9
• Protein Family: ABC transporter B family
• UniProt Gene Name: ABCB9
• UniProt Synonym Gene Names: KIAA1520; ABC transporter 9 protein; hABCB9; TAPL
• UniProt Entry Name: ABCB9_HUMAN

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]

Uniprot Description

ABCB9: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: lysosomal membrane; lysosome; endoplasmic reticulum; early endosome; integral to membrane; integral to endoplasmic reticulum membrane

Molecular Function: protein binding; protein homodimerization activity; substrate-specific transmembrane transporter activity; ATP binding; peptide-transporting ATPase activity

Biological Process: peptide transport; antigen processing and presentation of peptide antigen via MHC class I; protein transport; metabolic process; transmembrane transport