Rabbit anti-Human SLC19A1 Polyclonal Antibody | anti-SLC19A1 antibody
SLC19A1 Antibody
Gene Names
SLC19A1; CHMD; FOLT; IFC1; REFC; RFC1
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
SLC19A1; Polyclonal Antibody; SLC19A1 Antibody; CHMD; FLOT 1; FLOT1; Folate transporter 1; FOLT; IFC 1; IFC-1; IFC1; Intestinal folate carrier 1; Intestinal folate carrier; OTTHUMP00000115459; OTTHUMP00000115460; Placental folate transporter; Reduced folate carrier; Reduced folate carrier protein; REFC; RFC 1; RFC; RFC1; S19A1_HUMAN; Solute carrier family 19 member 1; anti-SLC19A1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
SLC19A1 Antibody detects endogenous levels of SLC19A1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-SLC19A1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human SLC19A1.
Conjugation
Unconjugated
Similarity
Belongs to the reduced folate carrier (RFC) transporter (TC 2. A. 48) family.
Tissue Specificity
Placenta, liver, and to a much smaller extent, in lung.
Function
Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP. Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-SLC19A1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
54,262 Da
NCBI Official Full Name
folate transporter 1 isoform 2
NCBI Official Synonym Full Names
solute carrier family 19 member 1
NCBI Official Symbol
SLC19A1
NCBI Official Synonym Symbols
CHMD; FOLT; IFC1; REFC; RFC1
NCBI Protein Information
folate transporter 1
UniProt Protein Name
Folate transporter 1
UniProt Gene Name
SLC19A1
UniProt Synonym Gene Names
FLOT1; RFC1; FOLT; IFC-1; RFC
UniProt Entry Name
S19A1_HUMAN
NCBI Description
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Uniprot Description
SLC19A1: a transporter protein. Transports reduced folate, antitumor agents and folate antagonists such as methotrexate. Apparently involved in methotrexate resistance in various cancers and neural tube defects.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; integral to plasma membrane; plasma membrane
Molecular Function: folic acid binding; folic acid transporter activity; methotrexate transporter activity; reduced folate carrier activity
Biological Process: female pregnancy; folic acid metabolic process; folic acid transport; methotrexate transport
Research Articles on SLC19A1
Similar Products
Product Notes
The SLC19A1 slc19a1 (Catalog #AAA9629896) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC19A1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC19A1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the SLC19A1 slc19a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC19A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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