Rabbit STAU2 Polyclonal Antibody | anti-STAU2 antibody

STAU2 Antibody

Cat. Num. AAA9629471

• Gene Names: STAU2; 39K2; 39K3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: STAU2; Polyclonal Antibody; STAU2 Antibody; 39K2; 39K3; DKFZp781K0371; Double stranded RNA binding protein Staufen homolog 2; Double-stranded RNA-binding protein Staufen homolog 2; MGC119606; STAU 2; stau2; STAU2_HUMAN; Staufen (Drosophila; RNA-binding protein) homolog 2; Staufen double-stranded RNA binding protein 2; Staufen homolog 2; Staufen RNA binding protein homolog 2; Staufen; RNA binding protein; homolog 2 (Drosophila); anti-STAU2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: STAU2 Antibody detects endogenous levels of total STAU2.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-STAU2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity).
• Subunit Structure: Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner.
• Function: RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity).
• Note: huttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-STAU2 antibody

Cytoplasm; Nucleus; Endoplasmic reticulum; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 73919458
• NCBI GeneID: 27067
• UniProt Accession #: Q9NUL3; Q6AHY7; Q96HM0; Q96HM1; Q9NVI5; B7Z1I6; B7Z292; B7Z8B4; E7ER74; E9PEI3; E9PF26; E9PF50
• Molecular Weight: 570
• NCBI Official Full Name: Double-stranded RNA-binding protein Staufen homolog 2
• NCBI Official Synonym Full Names: staufen double-stranded RNA binding protein 2
• NCBI Official Symbol: STAU2
• NCBI Official Synonym Symbols: 39K2; 39K3
• NCBI Protein Information: double-stranded RNA-binding protein Staufen homolog 2; staufen homolog 2; staufen, RNA binding protein, homolog 2
• UniProt Protein Name: Double-stranded RNA-binding protein Staufen homolog 2
• Protein Family: Double-stranded RNA-binding protein
• UniProt Gene Name: STAU2
• UniProt Entry Name: STAU2_HUMAN

NCBI Description

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

STAU2: RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: microtubule; membrane; endoplasmic reticulum; nucleolus

Molecular Function: protein binding; double-stranded RNA binding

Biological Process: transport