Rabbit CSN1 Polyclonal Antibody | anti-GPS1 antibody

CSN1 Antibody

Cat. Num. AAA9629254

• Gene Names: GPS1; CSN1; COPS1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: CSN1; Polyclonal Antibody; CSN1 Antibody; COP9 signalosome complex subunit 1; COP9 signalosome subunit 1; COPS1; CSN 1; CSN1_HUMAN; FUS6/COP11; Arabidopsis; homolog of; G protein pathway suppressor 1; GPS-1; Gps1; JAB1-containing signalosome subunit 1; Protein GPS1; Protein MFH; SGN1; Signalosome subunit 1; anti-GPS1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: CSN1 Antibody detects endogenous levels of total CSN1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPS1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity). The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression. Belongs to the CSN1 family.
• Subunit Structure: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5. Interacts directly with inositol kinase ITPK1. Interacts with CAPN8 (By similarity).
• Tissue Specificity: Widely expressed.
• Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-GPS1 antibody

Cytoplasm; Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 47078240
• NCBI GeneID: 2873
• NCBI Accession #: NP_004118.3
• NCBI GenBank Nucleotide #: NM_004127.4
• UniProt Accession #: Q13098; Q8NA10; Q9BWL1
• Molecular Weight: 55,537 Da
• NCBI Official Full Name: COP9 signalosome complex subunit 1 isoform 2
• NCBI Official Synonym Full Names: G protein pathway suppressor 1
• NCBI Official Symbol: GPS1
• NCBI Official Synonym Symbols: CSN1; COPS1
• NCBI Protein Information: COP9 signalosome complex subunit 1; SGN1; GPS-1; signalosome subunit 1; COP9 signalosome subunit 1; JAB1-containing signalosome subunit 1
• UniProt Protein Name: COP9 signalosome complex subunit 1
• UniProt Gene Name: GPS1
• UniProt Synonym Gene Names: COPS1; CSN1; SGN1; Signalosome subunit 1; GPS-1
• UniProt Entry Name: CSN1_HUMAN

NCBI Description

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

COPS1: a protein that suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. Shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells.

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: signalosome; cytoplasm; nucleus

Molecular Function: protein binding; GTPase inhibitor activity

Biological Process: cullin deneddylation; JNK cascade; cell cycle; inactivation of MAPK activity