Rabbit ROAA Polyclonal Antibody | anti-ROAA antibody

ROAA Antibody

Cat. Num. AAA9418163

• Gene Names: HNRNPAB; ABBP1; HNRPAB
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Synonyms: ROAA; Polyclonal Antibody; ROAA Antibody; HNRNPAB; anti-ROAA antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: ROAAantibody detects endogenous levels of total ROAA
• Form/Format: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0mg/mL (varies by lot)
• Sequence Length: 285

• Applicable Applications for anti-ROAA antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:500-1:2000
• Immunogen: A synthesized peptide derived from human ROAA
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of ROAA expression in HEK293 cells,The lane on the left is treated with the antigen-specific peptide.)

Product Categories/Family for anti-ROAA antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 55956921
• NCBI GeneID: 3182
• NCBI Accession #: NP_004490.2
• NCBI GenBank Nucleotide #: NM_004499.3
• UniProt Accession #: Q99729; Q04150; Q8N7U3; Q9BQ99; B3KNN5; D3DWP7
• Molecular Weight: 30,701 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein A/B isoform b
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein A/B
• NCBI Official Symbol: HNRNPAB
• NCBI Official Synonym Symbols: ABBP1; HNRPAB
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein A/B
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein A/B
• Protein Family: Ribosomal operon-associated A protein
• UniProt Gene Name: HNRNPAB
• UniProt Synonym Gene Names: ABBP1; HNRPAB; hnRNP A/B; ABBP-1
• UniProt Entry Name: ROAA_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

hnRNP A/B: a single-stranded RNA binding protein with two RNA-recognition (RRM) domains. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. Interacts with APOBEC1. Observed in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. A member of the RNA recognition motif (RRM) family. Four isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: cytoplasm; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; RNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: epithelial to mesenchymal transition; positive regulation of transcription, DNA-dependent