Rabbit anti-Human, Mouse FMNL1 Polyclonal Antibody | anti-FMNL1 antibody
FMNL1 Antibody
Gene Names
FMNL1; FMNL; FHOD4; KW-13; C17orf1; C17orf1B
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
FMNL1; Polyclonal Antibody; FMNL1 Antibody; 8030453N10Rik; AI553564; C17orf1; C17orf1B; CLL associated antigen KW 13; CLL-associated antigen KW-13; FHOD4; FMNL; FMNL_HUMAN; Fmnl1; Fnrl; Formin like 1; Formin like; Formin related protein; Formin-like protein 1; Frls; KW 13; KW13; Leukocyte formin; MGC133052; MGC1894; MGC21878; anti-FMNL1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
FMNL1 Antibody detects endogenous levels of total FMNL1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-FMNL1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
The DAD domain regulates activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity). Belongs to the formin homology family.
Post Translational Modifications
Myristoylation mediates membrane localization and blebbing.
Subunit Structure
Interacts with RAC1, PFN1 and PFN2 (By similarity). Interacts (activated by RAC1) with SRGAP2 (via SH3 domain); regulates the actin filament severing activity of FMNL1.
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Function
May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-FMNL1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
121 kDa
NCBI Official Full Name
formin-like protein 1
NCBI Official Synonym Full Names
formin-like 1
NCBI Official Symbol
FMNL1
NCBI Official Synonym Symbols
FMNL; FHOD4; KW-13; C17orf1; C17orf1B
NCBI Protein Information
formin-like protein 1; leukocyte formin; CLL-associated antigen KW-13
UniProt Protein Name
Formin-like protein 1
UniProt Gene Name
FMNL1
UniProt Synonym Gene Names
C17orf1; C17orf1B; FMNL
UniProt Entry Name
FMNL_HUMAN
NCBI Description
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
FMNL1: May play a role in the control of cell motility and survival of macrophages. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Belongs to the formin homology family. 3 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: membrane; plasma membrane; phagocytic vesicle; cell cortex; cytosol
Molecular Function: actin filament binding; protein binding; Rac GTPase binding; GTPase activating protein binding; profilin binding
Biological Process: substrate-bound cell migration; regulation of cell shape; actin filament severing; cortical actin cytoskeleton organization and biogenesis
Research Articles on FMNL1
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Product Notes
The FMNL1 fmnl1 (Catalog #AAA9629227) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FMNL1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FMNL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the FMNL1 fmnl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FMNL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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