Rabbit HIP1R Polyclonal Antibody | anti-HIP1R antibody
HIP1R Antibody
Gene Names
HIP1R; HIP3; HIP12; ILWEQ
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
HIP1R; Polyclonal Antibody; HIP1R Antibody; FLJ14000; FLJ27022; HIP-12; Hip1 related; HIP1-related protein; HIP12; HIP1R_HUMAN; HIP3; Huntingtin Interacting Protein 1 Related; Huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12; ILWEQ; KIAA0655; MGC47513; anti-HIP1R antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
HIP1R Antibody detects endogenous levels of total HIP1R.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-HIP1R antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
Binds F-actin via the talin-like I/LWEQ domain. Belongs to the SLA2 family.
Subunit Structure
Interacts with actin. Does not interact with huntingtin (By similarity). Interacts with CLTB and HIP1. Homodimer. Homodimerization promotes actin binding.
Tissue Specificity
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
Function
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Note
Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-HIP1R antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
1068
NCBI Official Full Name
Huntingtin-interacting protein 1-related protein
NCBI Official Synonym Full Names
huntingtin interacting protein 1 related
NCBI Official Symbol
HIP1R
NCBI Official Synonym Symbols
HIP3; HIP12; ILWEQ
NCBI Protein Information
huntingtin-interacting protein 1-related protein; HIP-12; HIP1-related protein; huntingtin interacting protein 12; huntingtin-interacting protein 12
UniProt Protein Name
Huntingtin-interacting protein 1-related protein
Protein Family
UniProt Gene Name
HIP1R
UniProt Synonym Gene Names
HIP12; KIAA0655; HIP1-related protein; HIP-12
UniProt Entry Name
HIP1R_HUMAN
Uniprot Description
HIP1R: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. Belongs to the SLA2 family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 12q24
Cellular Component: cytoskeleton; intracellular membrane-bound organelle; clathrin-coated vesicle; perinuclear region of cytoplasm; cytoplasm; clathrin coated vesicle membrane; coated pit
Molecular Function: protein binding, bridging; protein binding; actin binding; phosphoinositide binding
Biological Process: receptor-mediated endocytosis; actin cytoskeleton organization and biogenesis
Research Articles on HIP1R
Similar Products
Product Notes
The HIP1R hip1r (Catalog #AAA9629113) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HIP1R Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HIP1R can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the HIP1R hip1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HIP1R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
