BVES blocking peptide

BVES Blocking Peptide

Cat. Num. AAA9625404

• Gene Names: BVES; POP1; HBVES; POPDC1
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: BVES; BVES Blocking Peptide; Blood vessel epicardial substance; Bves; hBVES; MGC42413; POP 1; POP1; POPD1_HUMAN; POPDC 1; POPDC1; Popeye domain containing 1; Popeye domain containing protein 1; Popeye domain-containing protein 1; Popeye protein 1; BVES blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for BVES blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for BVES blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 313760596
• NCBI GeneID: 11149
• NCBI Accession #: NP_001186492.1
• NCBI GenBank Nucleotide #: NM_001199563.1
• UniProt Accession #: Q8NE79; Q5T550; Q5T551; Q8IWC6; Q9HBV0; Q9UNG6; A8K1R4; E1P5D8
• Molecular Weight: 41,451 Da
• NCBI Official Full Name: blood vessel epicardial substance
• NCBI Official Synonym Full Names: blood vessel epicardial substance
• NCBI Official Symbol: BVES
• NCBI Official Synonym Symbols: POP1; HBVES; POPDC1
• NCBI Protein Information: blood vessel epicardial substance; popeye protein 1; popeye domain containing 1; popeye domain-containing protein 1
• UniProt Protein Name: Blood vessel epicardial substance
• Protein Family: Blood vessel epicardial substance
• UniProt Gene Name: BVES
• UniProt Synonym Gene Names: POP1; POPDC1; hBVES; Popeye protein 1
• UniProt Entry Name: POPD1_HUMAN

NCBI Description

This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

BVES: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Belongs to the popeye family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: tight junction; plasma membrane; integral to membrane; lateral plasma membrane

Molecular Function: cAMP binding; structural molecule activity

Biological Process: vesicle-mediated transport; regulation of cell shape; regulation of membrane potential; muscle development; positive regulation of locomotion; regulation of heart rate; hemopoietic progenitor cell differentiation; positive regulation of receptor recycling