ADP-ribosyl cyclase 1 (CD38) Recombinant Protein | CD38 recombinant protein

Recombinant Human ADP-ribosyl cyclase 1 (CD38)

Cat. Num. AAA962038

• Gene Names: CD38; T10; ADPRC 1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: ADP-ribosyl cyclase 1 (CD38); Recombinant Human ADP-ribosyl cyclase 1 (CD38); ADP-ribosyl cyclase 1; EC=3.2.2.5; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen=; CD38; CD38 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 43-300
• Sequence: VPRWRQQW SGPGTTKRFP ETVLARCVKY TEIHPEMRHV DCQSVWDAFK GAFISKHPCN ITEEDYQPLM KLGTQTVPCN KILLWSRIKD LAHQFTQVQR DMFTLEDTLL GYLADDLTWC GEFNTSKINY QSCPDWRKDC SNNPVSVFWK TVSRRFAEAA CDVVHVMLNG SRSKIFDKNS TFGSVEVHNL QPEKVQTLEA WVIHGGREDS RDLCQDPTIK ELESIISKRN IQFSCKNIYR PDKFLQCVKN PEDSSCTSEI
• Sequence Length: 258

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 38454326
• NCBI GeneID: 952
• NCBI Accession #: NP_001766.2
• NCBI GenBank Nucleotide #: NM_001775.2
• UniProt Accession #: P28907; O00121; O00122; Q96HY4
• Molecular Weight: 62.2
• NCBI Official Full Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• NCBI Official Synonym Full Names: CD38 molecule
• NCBI Official Symbol: CD38
• NCBI Official Synonym Symbols: T10; ADPRC 1
• NCBI Protein Information: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; ADP-ribosyl cyclase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
• UniProt Protein Name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
• Protein Family: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
• UniProt Gene Name: CD38
• UniProt Synonym Gene Names: ADPRC 1; cADPr hydrolase 1
• UniProt Entry Name: CD38_HUMAN

NCBI Description

CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]

Uniprot Description

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Apoptosis; EC 3.2.2.6; Hydrolase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cell surface; Lyase; EC 2.4.99.20; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; nucleus

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; B cell receptor signaling pathway; response to hydroperoxide; response to hypoxia; positive regulation of vasoconstriction; positive regulation of B cell proliferation; negative regulation of transcription, DNA-dependent; response to progesterone stimulus; negative regulation of bone resorption; negative regulation of apoptosis