Rabbit anti-Human BAZ1B Polyclonal Antibody | anti-BAZ1B antibody

BAZ1B Antibody

Cat. Num. AAA9608698

• Gene Names: BAZ1B; WSTF; WBSCR9; WBSCR10
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: BAZ1B; Polyclonal Antibody; BAZ1B Antibody; baz1b; BAZ1B_HUMAN; Bromodomain adjacent to zinc finger domain protein 1B; hWALP 2; hWALP-2; hWALP2; transcription factor WSTF; Tyrosine-protein kinase BAZ1B; WALP-2; WALP2; WBRS 9; WBRS-9; WBRS9; WBSC 10; WBSC-10; WBSC10; WBSCR10; WBSCR9; Williams Beuren syndrome chromosome region 9 protein; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; WSTF; anti-BAZ1B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: BAZ1B antibody detects endogenous levels of total BAZ1B
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 1483

• Applicable Applications for anti-BAZ1B antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-3000
• Immunogen: A synthesized peptide derived from human BAZ1B
• Subcellular Location: Nucleus. Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.
• Tissue Specificity: Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.
• Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog
• Similarity: Pig (100%), Bovine (92%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (92%)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of BAZ1B using COLO205 whole cell lysates)

Related Product Information for anti-BAZ1B antibody

Function: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
Subunit Structure: Interacts with MYO1C (By similarity). Interacts with CDT1. Interacts with SMARCA5/SNF2H; the interaction is direct and forms the WICH complex. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with VDR; in a ligand-dependent manner. Interacts with PCNA; the interaction is direct.
Similarity: The N-terminal part (1-345), including the WAC domain and the C motif, mediates the tyrosine-protein kinase activity.The bromo domain mediates the specific interaction with acetylated histones. Belongs to the WAL family. BAZ1B subfamily.

NCBI and Uniprot Product Information

• NCBI GI #: 14670392
• NCBI GeneID: 9031
• NCBI Accession #: NP_115784.1
• NCBI GenBank Nucleotide #: NM_032408.3
• UniProt Accession #: Q9UIG0; O95039; O95247; O95277; Q6P1K4; Q86UJ6; B9EGK3; D3DXE9
• Molecular Weight: Observed: 185 kDa; Predicted: 171 kDa
• NCBI Official Full Name: tyrosine-protein kinase BAZ1B
• NCBI Official Synonym Full Names: bromodomain adjacent to zinc finger domain 1B
• NCBI Official Symbol: BAZ1B
• NCBI Official Synonym Symbols: WSTF; WBSCR9; WBSCR10
• NCBI Protein Information: tyrosine-protein kinase BAZ1B
• UniProt Protein Name: Tyrosine-protein kinase BAZ1B
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: BAZ1B
• UniProt Synonym Gene Names: WBSC10; WBSCR10; WBSCR9; WSTF

NCBI Description

This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]

Uniprot Description

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.