Interleukin-1 receptor accessory protein-like 1 (Il1rapl1) Recombinant Protein | Il1rapl1 recombinant protein

Recombinant Rat Interleukin-1 receptor accessory protein-like 1 (Il1rapl1)

• Gene Names: Il1rapl1; Il1rapl
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Interleukin-1 receptor accessory protein-like 1 (Il1rapl1); Recombinant Rat Interleukin-1 receptor accessory protein-like 1 (Il1rapl1); Interleukin-1 receptor accessory protein-like 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1; Il1rapl1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 25-357
• Sequence: RGSADG CTDWSVDIKK YQVLVGEPVR IKCALFYGYI RTNYTLAQSA GLSLMWYKSS GPGDFEEPIA FDGSRMSKEE DSIWFRPTLL QDSGLYACVI RNSTYCMKVS ISLTVGENDT GLCYNSKMKY FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIKEVKEDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES KLTIQETQLG GSANLTCRAF FGYSGDVSPL IYWMKGEKFI EDLDENRVWE SDIRILKEHL GEQEVSISLI VDSVEEGDLG NYSCYVENGN GRRHASVLLH KRELMYT
• Sequence Length: 333

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 29293825
• NCBI GeneID: 317553
• NCBI Accession #: NP_808796.1
• NCBI GenBank Nucleotide #: NM_177935.2
• UniProt Accession #: P59824
• Molecular Weight: 79,771 Da
• NCBI Official Full Name: interleukin-1 receptor accessory protein-like 1
• NCBI Official Synonym Full Names: interleukin 1 receptor accessory protein-like 1
• NCBI Official Symbol: Il1rapl1
• NCBI Official Synonym Symbols: Il1rapl
• NCBI Protein Information: interleukin-1 receptor accessory protein-like 1; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1
• UniProt Protein Name: Interleukin-1 receptor accessory protein-like 1
• Protein Family: Interleukin-1 receptor accessory protein
• UniProt Gene Name: Il1rapl1
• UniProt Synonym Gene Names: IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1
• UniProt Entry Name: IRPL1_RAT

NCBI Description

member of the interleukin 1 receptor family; mutation of human homolog may be involved is associated with X-linked mental retardation [RGD, Feb 2006]

Uniprot Description

IL1RAPL1: May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the interleukin-1 receptor family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: cell surface; axon; cytoplasm; dendrite; integral to membrane; plasma membrane

Molecular Function: voltage-gated calcium channel activity; interleukin-1 binding; receptor binding

Biological Process: heterophilic cell adhesion; neuron differentiation; negative regulation of exocytosis; positive regulation of dendrite morphogenesis; signal transduction