CDC2 elisa kit
Phospho-CDC2 (Thr161) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Description
CDK1: a protein kinase of the CDK family. Catalytic subunit of the conserved protein complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions. Mitotic cyclins stably associate with this protein and function as regulatory subunits. Its activity is controlled by cyclin availability and phosphorylation through the cell cycle. Activated in many cancers including colon, liver and breast. The T isoform, which lacks a regulatory region, is expressed in breast cancer. Inhibition in cancer cells may drive cells into apoptosis. May also drive cell migration. Inhibitors: BMS-265246, BMS-265246-01. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: CDK family; CDK/CDK1 subfamily; CDK1 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 10q21.2
Cellular Component: centrosome; cyclin-dependent protein kinase holoenzyme complex; cytosol; endoplasmic reticulum membrane; extracellular exosome; membrane; midbody; mitochondrial matrix; mitochondrion; nuclear chromosome, telomeric region; nucleoplasm; nucleus; spindle microtubule
Molecular Function: ATP binding; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; Hsp70 protein binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; viral receptor activity
Biological Process: activation of MAPK activity; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; apoptosis; cell aging; cell division; cell migration; cell proliferation; cellular response to hydrogen peroxide; centrosome cycle; chromosome condensation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication; entry of virus into host cell; epithelial cell differentiation; G2/M transition of mitotic cell cycle; Golgi disassembly; histone phosphorylation; microtubule cytoskeleton organization; mitotic cell cycle G2/M transition DNA damage checkpoint; mitotic nuclear envelope disassembly; negative regulation of apoptosis; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; organ regeneration; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of DNA replication; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of protein import into nucleus, translocation; positive regulation of protein localization to nucleus; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; pronuclear fusion; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; protein complex assembly; protein deubiquitination; protein localization to kinetochore; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of embryonic development; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; regulation of meiotic cell cycle; regulation of Schwann cell differentiation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; response to activity; response to amine; response to axon injury; response to cadmium ion; response to copper ion; response to drug; response to ethanol; response to organic cyclic compound; response to toxin; transcription initiation from RNA polymerase II promoter; ventricular cardiac muscle cell development
Research Articles on CDC2
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Product Notes
The Human, Mouse, Rat CDC2 cdk1 (Catalog #AAA9501412) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501412 ELISA Kit recognizes Human, Mouse, Rat CDC2. It is sometimes possible for the material contained within the vial of "CDC2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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