PKA alpha/beta CAT ELISA Kit | PRKACA/PRKACB elisa kit
Phospho-PKA alpha/beta CAT (Thr197) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
Uniprot Description
PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described.
Protein type: AGC group; EC 2.7.11.11; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: acrosomal vesicle; axoneme; calcium channel complex; cAMP-dependent protein kinase complex; centrosome; cytoplasm; cytosol; extracellular exosome; intercellular bridge; membrane; mitochondrion; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: ATP binding; cAMP-dependent protein kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: activation of protein kinase A activity; blood coagulation; cell communication by electrical coupling involved in cardiac conduction; cellular response to epinephrine stimulus; cellular response to glucagon stimulus; cellular response to glucose stimulus; cellular response to heat; G2/M transition of mitotic cell cycle; high-density lipoprotein particle assembly; mRNA processing; peptidyl-serine phosphorylation; positive regulation of cell cycle arrest; protein amino acid phosphorylation; regulation of bicellular tight junction assembly; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; regulation of cytosolic calcium ion concentration; regulation of G2/M transition of mitotic cell cycle; regulation of heart rate; regulation of macroautophagy; regulation of osteoblast differentiation; regulation of protein binding; renal water homeostasis; sperm capacitation; stimulatory C-type lectin receptor signaling pathway
Research Articles on PRKACA/PRKACB
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Product Notes
The Human, Mouse, Rat PRKACA/PRKACB prkaca (Catalog #AAA9501144) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501144 ELISA Kit recognizes Human, Mouse, Rat PRKACA/PRKACB. It is sometimes possible for the material contained within the vial of "PKA alpha/beta CAT, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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