C/EBP-alpha elisa kit
Phospho-C/EBP-alpha (Ser21) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Uniprot Description
C/EBP-alpha: a bZIP transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.11
Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function: DNA binding; DNA binding transcription factor activity; kinase binding; protein binding; protein homodimerization activity; transcription coactivator activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process: brown fat cell differentiation; cell maturation; cellular response to lithium ion; cellular response to organic cyclic compound; cellular response to tumor necrosis factor; cholesterol metabolic process; cytokine-mediated signaling pathway; embryonic placenta development; fat cell differentiation; generation of precursor metabolites and energy; glucose homeostasis; granulocyte differentiation; inner ear development; lipid homeostasis; liver development; lung development; macrophage differentiation; mitochondrion organization; myeloid cell differentiation; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of fat cell differentiation; positive regulation of osteoblast differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; transcription from RNA polymerase II promoter; transcription, DNA-dependent; urea cycle; viral process; white fat cell differentiation
Disease: Leukemia, Acute Myeloid