Human PKR ELISA Kit | PKR elisa kit
PKR Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
PKR: a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats. Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation.
Protein type: EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; Other group; PEK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation
Chromosomal Location of Human Ortholog: 2p22.2
Cellular Component: cytoplasm; cytosol; membrane; nucleus; perinuclear region of cytoplasm; ribosome
Molecular Function: ATP binding; double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein phosphatase regulator activity; protein serine/threonine kinase activity; RNA binding
Biological Process: activation of MAPKK activity; cellular response to amino acid starvation; defense response to virus; endoplasmic reticulum unfolded protein response; evasion by virus of host immune response; innate immune response; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; peptidyl-tyrosine phosphorylation; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of stress-activated MAPK cascade; protein amino acid phosphorylation; protein autophosphorylation; regulation of hematopoietic progenitor cell differentiation; regulation of hematopoietic stem cell differentiation; regulation of hematopoietic stem cell proliferation; regulation of NLRP3 inflammasome complex assembly; regulation of translational initiation by eIF2 alpha phosphorylation; response to toxin; response to virus; transcription, DNA-dependent; translation
