CSK elisa kit
CSK Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Uniprot Description
CSK: a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development.
Protein type: Csk family; EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: cytoplasm; cytosol; extracellular exosome; extrinsic component of cytoplasmic side of plasma membrane; intercellular junction; membrane raft; plasma membrane
Molecular Function: ATP binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; proline-rich region binding; protein binding; protein C-terminus binding; protein phosphatase binding; protein tyrosine kinase activity; receptor binding
Biological Process: adaptive immune response; brain development; cell differentiation; cellular response to peptide hormone stimulus; central nervous system development; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of Golgi to plasma membrane protein transport; negative regulation of interleukin-6 production; negative regulation of kinase activity; negative regulation of low-density lipoprotein particle clearance; negative regulation of phagocytosis; oligodendrocyte differentiation; peptidyl-tyrosine autophosphorylation; positive regulation of MAP kinase activity; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on CSK
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Product Notes
The Human, Mouse, Rat CSK csk (Catalog #AAA9500154) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500154 ELISA Kit recognizes Human, Mouse, Rat CSK. It is sometimes possible for the material contained within the vial of "CSK, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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