Rabbit CCR7 CD197 Polyclonal Antibody | anti-CCR7 antibody

CCR7 CD197 Polyclonal Antibody Cy3 Conjugated

Cat. Num. AAA9460560

• Gene Names: Ccr7; EBI1; CCR-7; CD197; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Flow Cytometry, Functional Assay
• Purity: Purified by Protein A
• Synonyms: CCR7 CD197; Polyclonal Antibody; CCR7 CD197 Polyclonal Antibody Cy3 Conjugated; EBI1; CCR-7; CD197; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7; C-C chemokine receptor type 7; C-C CKR-7; Epstein-Barr virus-induced G-protein coupled receptor 1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; Ccr7; anti-CCR7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-CCR7 antibody: Immunofluorescence (IF), Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS:1:20-10; IF: 1:50-200
• Conjugation: Cy3
• Excitation Emission: 512,550nm 570,615nm
• Immunogen: KLH conjugated synthetic peptide aa 25-59 379 derived from mouse CCR7
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-CCR7 antibody

CCR7 is a member of the G protein coupled receptor family (subfamily : chemokine). This receptor was identified as a gene induced by the Epstein Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. It is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19 ECL) has been reported to be a specific ligand of this receptor. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries.

Product Categories/Family for anti-CCR7 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 678246450
• NCBI GeneID: 12775
• NCBI Accession #: NP_001288642.1
• NCBI GenBank Nucleotide #: NM_001301713.1
• UniProt Accession #: P47774; Q8CAS2
• Molecular Weight: 42,856 Da
• NCBI Official Full Name: C-C chemokine receptor type 7 isoform b
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 7
• NCBI Official Symbol: Ccr7
• NCBI Official Synonym Symbols: EBI1; CCR-7; CD197; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7
• NCBI Protein Information: C-C chemokine receptor type 7
• UniProt Protein Name: C-C chemokine receptor type 7
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: Ccr7
• UniProt Synonym Gene Names: Cmkbr7; Ebi1; Ebi1h; C-C CKR-7; CC-CKR-7; CCR-7; EBI1; EBV-induced G-protein coupled receptor 1
• UniProt Entry Name: CCR7_MOUSE

Uniprot Description

CCR7: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 1; Receptor, GPCR

Cellular Component: cell surface; external side of plasma membrane; integral to membrane; intracellular; membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; G-protein coupled receptor activity; protein binding; signal transducer activity

Biological Process: actin cytoskeleton organization and biogenesis; activation of JNK activity; chemotaxis; establishment of T cell polarity; G-protein coupled receptor protein signaling pathway; homeostasis of number of cells; immune response; inflammatory response; lymph node development; lymphocyte chemotaxis across high endothelial venule; myeloid dendritic cell chemotaxis; negative thymic T cell selection; positive regulation of dendritic cell antigen processing and presentation; positive regulation of filopodium formation; positive regulation of GTPase activity; positive regulation of humoral immune response; positive regulation of hypersensitivity; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-12 production; positive regulation of phagocytosis; positive regulation of receptor-mediated endocytosis; positive regulation of T cell proliferation; positive regulation of T cell receptor signaling pathway; positive regulation of T-helper 1 cell differentiation; positive regulation of tumor necrosis factor production; regulation of interferon-gamma production; regulation of interleukin-1 beta secretion; regulation of tolerance induction to self antigen; response to lipopolysaccharide; signal transduction