Rabbit TRIP13 16E1BP Polyclonal Antibody | anti-TRIP13 antibody

TRIP13 16E1BP Antibody FITC Conjugated

Cat. Num. AAA9460372

• Gene Names: TRIP13; 16E1BP
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence
• Purity: Purified by Protein A
• Synonyms: TRIP13 16E1BP; Polyclonal Antibody; TRIP13 16E1BP Antibody FITC Conjugated; 16E1-BP; 16E1BP; Homo sapiens HPV16 E1 protein binding protein mRNA complete cds; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; Human papillomavirus type 16 E1 protein binding protein; Human papillomavirus type 16 E1 protein-binding protein; Pachytene checkpoint protein 2 homol; anti-TRIP13 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-TRIP13 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-200
• Conjugation: FITC
• Excitation Emission: 494nm 518nm
• Immunogen: KLH conjugated synthetic peptide derived from human TRIP13 16E1BP
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-TRIP13 antibody

Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner. TRIP13 is a transcription factor that interacts with the ligand binding domain of the thyroid receptor (TR) as well as a variety of target genes including human papilloma virus type 16 (HPV16) E1. Unlike most TRIP proteins which function only in the presence of hormones, TRIP13 does not require the presence of thyroid hormone to interact with TR. The association of TRIP13 with (HPV16) E1 suggests that TRIP13 may have tumor suppressor gene function. TRIP13 is a 432 amino acid protein with 2 different isoforms produced by alternative splicing.

Product Categories/Family for anti-TRIP13 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 11321607
• NCBI GeneID: 9319
• NCBI Accession #: NP_004228.1
• NCBI GenBank Nucleotide #: NM_004237.3
• UniProt Accession #: Q15645; O15324; C9K0T3; D3DTC0
• Molecular Weight: 48,551 Da
• NCBI Official Full Name: pachytene checkpoint protein 2 homolog isoform 1
• NCBI Official Synonym Full Names: thyroid hormone receptor interactor 13
• NCBI Official Symbol: TRIP13
• NCBI Official Synonym Symbols: 16E1BP
• NCBI Protein Information: pachytene checkpoint protein 2 homolog; 16E1-BP; TRIP-13; TR-interacting protein 13; HPV16 E1 protein binding protein; HPV16 E1 protein-binding protein; thyroid receptor interacting protein 13; thyroid receptor-interacting protein 13; human papillomavirus
• UniProt Protein Name: Pachytene checkpoint protein 2 homolog
• UniProt Gene Name: TRIP13
• UniProt Synonym Gene Names: PCH2; 16E1-BP; HPV16 E1 protein-binding protein; TR-interacting protein 13; TRIP-13
• UniProt Entry Name: PCH2_HUMAN

NCBI Description

This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]

Uniprot Description

TRIP13: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Belongs to the AAA ATPase family. PCH2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: male germ cell nucleus; nucleus

Molecular Function: identical protein binding; protein binding; transcription cofactor activity; ATP binding

Biological Process: oogenesis; transcription from RNA polymerase II promoter; synaptonemal complex assembly; male meiosis I; meiotic recombination; double-strand break repair; spermatogenesis; oocyte maturation; spermatid development; female meiosis I