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Western Blot (WB) (Western blot analysis of Periostin on human placenta tissue lysate using anti-Periostin antibody at 1/1, 000 dilution.)

Rabbit anti-Human Periostin Monoclonal Antibody | anti-POSTN antibody

Periostin Antibody

Gene Names
POSTN; PN; OSF2; OSF-2; PDLPOSTN; periostin
Reactivity
Human
Applications
Western Blot, Flow Cytometry, Functional Assay
Purity
ProA affinity purified
Synonyms
Periostin; Monoclonal Antibody; Periostin Antibody; Fasciclin-I like antibody; MGC119510 antibody; MGC119511 antibody; OSF 2 antibody; OSF-2 antibody; OSF2 antibody; Osteoblast specific factor 2 (fasciclin I like) antibody; Osteoblast specific factor 2 antibody; Osteoblast specific factor antibody; Osteoblast-specific factor 2 antibody; PDLPOSTN antibody; Periodontal ligament specific periostin antibody; Periostin antibody; Periostin isoform thy2 antibody; Periostin isoform thy4 antibody; Periostin isoform thy6 antibody; Periostin isoform thy8 antibody; Periostin osteoblast specific factor antibody; PN antibody; POSTN antibody; POSTN_HUMAN antibody; RP11 412K4.1 antibody; anti-POSTN antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Clone Number
JA63-40
Purity/Purification
ProA affinity purified
Form/Format
1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Applicable Applications for anti-POSTN antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes
WB: 1:500-1:2000
FC/FACS: 1:50-1:100
Antibody Type
Recombinant Antibody
Immunogen
Recombinant protein
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.

Western Blot (WB)

(Western blot analysis of Periostin on human placenta tissue lysate using anti-Periostin antibody at 1/1, 000 dilution.)

Western Blot (WB) (Western blot analysis of Periostin on human placenta tissue lysate using anti-Periostin antibody at 1/1, 000 dilution.)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of 293T cells with Periostin antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).)

Flow Cytometry (FC/FACS) (Flow cytometric analysis of 293T cells with Periostin antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).)
Related Product Information for anti-POSTN antibody
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha (V)beta and alpha (V)beta integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
Product Categories/Family for anti-POSTN antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
93,314 Da
NCBI Official Full Name
periostin isoform 1
NCBI Official Synonym Full Names
periostin, osteoblast specific factor
NCBI Official Symbol
POSTN
NCBI Official Synonym Symbols
PN; OSF2; OSF-2; PDLPOSTN; periostin
NCBI Protein Information
periostin; periodontal ligament-specific periostin; osteoblast specific factor 2 (fasciclin I-like)
UniProt Protein Name
Periostin
Protein Family
UniProt Gene Name
POSTN
UniProt Synonym Gene Names
OSF2; PN; OSF-2
UniProt Entry Name
POSTN_HUMAN

NCBI Description

This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Uniprot Description

POSTN: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Cell adhesion; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; trans-Golgi network

Molecular Function: heparin binding; protein binding; cell adhesion molecule binding

Biological Process: tissue development; extracellular matrix organization and biogenesis; regulation of Notch signaling pathway; cell adhesion; skeletal development

Research Articles on POSTN

Similar Products

Product Notes

The POSTN postn (Catalog #AAA9436315) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Periostin Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Periostin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Flow Cytometry (FC/FACS). WB: 1:500-1:2000 FC/FACS: 1:50-1:100. Researchers should empirically determine the suitability of the POSTN postn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Periostin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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