Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using MICAL1 antibody.)
Rabbit anti-Human MICAL1 Polyclonal Antibody | anti-MICAL1 antibody
MICAL1 Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using MICAL1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using MICAL1 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Description
MICAL1: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Belongs to the Mical family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; EC 1.14.13.-
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; intermediate filament
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; protein binding; zinc ion binding; actin binding; SH3 domain binding; Rab GTPase binding
Biological Process: actin filament depolymerization; negative regulation of protein amino acid phosphorylation; cytoskeleton organization and biogenesis; negative regulation of caspase activity; signal transduction; sulfur oxidation
Research Articles on MICAL1
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Product Notes
The MICAL1 mical1 (Catalog #AAA9432600) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MICAL1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MICAL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:200-1:2000. Researchers should empirically determine the suitability of the MICAL1 mical1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MICAL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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