Rat Sodium/potassium-transporting ATPase subunit alpha-3 ELISA Kit | Atp1a3 elisa kit

Rat Sodium/potassium-transporting ATPase subunit alpha-3 ELISA Kit

Cat. Num. AAA9426637

• Gene Names: Atp1a3; Atpa1a3
• Reactivity: Rat
• Synonyms: Sodium/potassium-transporting ATPase subunit alpha-3; Rat Sodium/potassium-transporting ATPase subunit alpha-3 ELISA Kit; Na (+)/K (+) ATPase alpha-3 subunit; Na (+)/K (+) ATPase alpha (III) subunit; Sodium pump subunit alpha-3; Atp1a3; 3.6.3.9; Atp1a3 elisa kit

• Reactivity: Rat

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Detection Range: 78-5000 pg/mL
• Assay Time: 3-5h
• Sample Volume: 100T
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 4 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 6978547
• NCBI GeneID: 24213
• NCBI Accession #: NP_036638.1
• NCBI GenBank Nucleotide #: NM_012506.1
• UniProt Accession #: P06687; Q16732; Q9Z1G6
• Molecular Weight: 111,692 Da
• NCBI Official Full Name: sodium/potassium-transporting ATPase subunit alpha-3
• NCBI Official Synonym Full Names: ATPase Na+/K+ transporting subunit alpha 3
• NCBI Official Symbol: Atp1a3
• NCBI Official Synonym Symbols: Atpa1a3
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit alpha-3
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit alpha-3
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: Atp1a3
• UniProt Synonym Gene Names: Na(+)/K(+) ATPase alpha-3 subunit

NCBI Description

contains 4.5 kb and 6 kb transcripts that display differential tissue expression [RGD, Feb 2006]

Uniprot Description

ATP1A3: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Defects in ATP1A3 are the cause of dystonia type 12 (DYT12); also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant dystonia- parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Protein type: EC 3.6.3.9; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: axon; cell soma; cytoplasm; endoplasmic reticulum; Golgi apparatus; membrane; myelin sheath; nucleus; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex; synapse

Molecular Function: beta-amyloid binding; chaperone binding; D1 dopamine receptor binding; heparan sulfate proteoglycan binding; protein binding; sodium:potassium-exchanging ATPase activity

Biological Process: adult locomotory behavior; cardiac muscle contraction; cellular potassium ion homeostasis; cellular sodium ion homeostasis; cerebral cortex development; ionotropic glutamate receptor signaling pathway; memory; potassium ion import; potassium ion transport; response to drug; sodium ion transport; visual learning